1pqs: Difference between revisions

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[[Image:1pqs.gif|left|200px]]
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[[Image:1pqs.png|left|200px]]


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{{STRUCTURE_1pqs|  PDB=1pqs  |  SCENE=  }}  
{{STRUCTURE_1pqs|  PDB=1pqs  |  SCENE=  }}  


'''Solution structure of the C-terminal OPCA domain of yCdc24p'''
===Solution structure of the C-terminal OPCA domain of yCdc24p===




==Overview==
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Phox and Bem1 (PB1) domains mediate protein-protein interactions via the formation of homo- or hetero-dimers. The C-terminal PB1 domain of yeast cell division cycle 24 (CDC24p), a guanine-nucleotide exchange factor involved in cell polarity establishment, is known to interact with the PB1 domain occurring in bud emergence MSB1 interacting 1 (BEM1p) during the regulation of the yeast budding process via its OPR/PC/AID (OPCA) motif. Here, we present the structure of an N-terminally truncated version of the Sc CDC24p PB1 domain. It shows a different topology of the beta-sheet than the long form. However, the C-terminal part of the structure shows the conserved PB1 domain features including the OPCA motif with a slight rearrangement of helix alpha1. Residues which are important for the heterodimerization with BEM1p are structurally preserved.
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{{ABSTRACT_PUBMED_15961083}}


==About this Structure==
==About this Structure==
1PQS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQS OCA].  
1PQS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQS OCA].  


==Reference==
==Reference==
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[[Category: Wahl, M.]]
[[Category: Wahl, M.]]
[[Category: Alpha and beta protein]]
[[Category: Alpha and beta protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:22:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:09:29 2008''

Revision as of 12:09, 29 July 2008

File:1pqs.png

Template:STRUCTURE 1pqs

Solution structure of the C-terminal OPCA domain of yCdc24p

Template:ABSTRACT PUBMED 15961083

About this Structure

1PQS is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

The solution structure of an N-terminally truncated version of the yeast CDC24p PB1 domain shows a different beta-sheet topology., Leitner D, Wahl M, Labudde D, Krause G, Diehl A, Schmieder P, Pires JR, Fossi M, Wiedemann U, Leidert M, Oschkinat H, FEBS Lett. 2005 Jul 4;579(17):3534-8. PMID:15961083

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