8hko: Difference between revisions

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'''Unreleased structure'''


The entry 8hko is ON HOLD  until 2025-04-27
==Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Rucaparib==
 
<StructureSection load='8hko' size='340' side='right'caption='[[8hko]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Wang, X.Y., Zhou, J., Xu, B.L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8hko]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HKO FirstGlance]. <br>
Description: Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Rucaparib
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=RPB:RUCAPARIB'>RPB</scene></td></tr>
[[Category: Xu, B.L]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hko OCA], [https://pdbe.org/8hko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hko RCSB], [https://www.ebi.ac.uk/pdbsum/8hko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hko ProSAT]</span></td></tr>
[[Category: Wang, X.Y]]
</table>
[[Category: Zhou, J]]
== Function ==
[https://www.uniprot.org/uniprot/PARP2_HUMAN PARP2_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wang XY]]
[[Category: Xu BL]]
[[Category: Zhou J]]
Retrieved from "https://proteopedia.org/8hko"