8y1e: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8y1e is ~~ON HOLD~~

==3up-TM conformation of HKU1-B S protein after incubation of the receptor==

~~Authors~~: ~~Xia~~, L.Y., ~~Zhang~~, Y.Y., ~~Zhou~~, Q.

== Structural highlights ==

<table><tr><td colspan='2'>[[8y1e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_coronavirus_HKU1_(isolate_N2) Human coronavirus HKU1 (isolate N2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y1E OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8Y1E FirstGlance].

~~Description~~: ~~3up~~-~~TM conformation~~ of ~~HKU1~~-~~B S protein after incubation~~ of the ~~receptor~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Zhang, Y.Y~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8y1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y1e OCA], [https://pdbe.org/8y1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y1e RCSB], [https://www.ebi.ac.uk/pdbsum/8y1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y1e ProSAT]</td></tr>

[[Category: ~~Zhou, Q~~]]

</table>

[[Category: ~~Xia, L.Y~~]]

== Function ==

[https://www.uniprot.org/uniprot/SPIKE_CVHN2 SPIKE_CVHN2] Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Xia LY]]

[[Category: Zhang YY]]

[[Category: Zhou Q]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8y1e is ON HOLD
+==3up-TM conformation of HKU1-B S protein after incubation of the receptor==
+<StructureSection load='8y1e' size='340' side='right'caption='[[8y1e]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Xia, L.Y., Zhang, Y.Y., Zhou, Q.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8y1e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_coronavirus_HKU1_(isolate_N2) Human coronavirus HKU1 (isolate N2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y1E FirstGlance]. <br>
-Description: 3up-TM conformation of HKU1-B S protein after incubation of the receptor
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Zhang, Y.Y]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y1e OCA], [https://pdbe.org/8y1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y1e RCSB], [https://www.ebi.ac.uk/pdbsum/8y1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y1e ProSAT]</span></td></tr>
-[[Category: Zhou, Q]]
+</table>
-[[Category: Xia, L.Y]]
+== Function ==
+[https://www.uniprot.org/uniprot/SPIKE_CVHN2 SPIKE_CVHN2] Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099]  Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]  Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Xia LY]]
+[[Category: Zhang YY]]
+[[Category: Zhou Q]]