1ptv: Difference between revisions

Line 1:

[[Image:1ptv.~~gif~~|left|200px]]

[[Image:1ptv.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE~~'''~~

===CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE===

~~==Overview==~~

<!--

The ~~crystal structures of a cysteine-215-->serine mutant of protein tyrosine phosphatase 1B complexed with high-affinity peptide substrates corresponding~~ to ~~an autophosphorylation site of~~ the ~~epidermal growth factor receptor were determined~~. Peptide binding to the protein phosphatase was accompanied by a conformational change of a surface loop that created a phosphotyrosine recognition pocket and induced a catalytically competent form of the enzyme. ~~The phosphotyrosine side chain~~ is ~~buried within the period and anchors~~ the ~~peptide substrate to its binding site~~. ~~Hydrogen bonds between peptide main~~-~~chain atoms and the protein contribute to binding affinity, and specific interactions of acidic residues of the peptide with basic residues on the surface of the enzyme confer sequence specificity.~~

The line below this paragraph, {{ABSTRACT_PUBMED_7540771}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7540771 is the PubMed ID number.

-->

==About this Structure==

Line 29:

Line 33:

[[Category: Peptide]]

[[Category: Phosphorylation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:28:37 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:38:56 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1ptv.gif|left|200px]]
+{{Seed}}
+[[Image:1ptv.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ptv|  PDB=1ptv  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE'''
+===CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE===
-==Overview==
+<!--
-The crystal structures of a cysteine-215--&gt;serine mutant of protein tyrosine phosphatase 1B complexed with high-affinity peptide substrates corresponding to an autophosphorylation site of the epidermal growth factor receptor were determined. Peptide binding to the protein phosphatase was accompanied by a conformational change of a surface loop that created a phosphotyrosine recognition pocket and induced a catalytically competent form of the enzyme. The phosphotyrosine side chain is buried within the period and anchors the peptide substrate to its binding site. Hydrogen bonds between peptide main-chain atoms and the protein contribute to binding affinity, and specific interactions of acidic residues of the peptide with basic residues on the surface of the enzyme confer sequence specificity.
+The line below this paragraph, {{ABSTRACT_PUBMED_7540771}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7540771 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7540771}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Peptide]]
 [[Category: Phosphorylation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:28:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:38:56 2008''