8i74: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/OSTCN_BOVIN OSTCN_BOVIN] Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | [https://www.uniprot.org/uniprot/OSTCN_BOVIN OSTCN_BOVIN] Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | ||
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== Publication Abstract from PubMed == | |||
An acidic environment in bone is essential for bone metabolism and the production of decarboxylated osteocalcin, which functions as a regulatory hormone of glucose metabolism. Here, we describe the high-resolution X-ray crystal structure of decarboxylated osteocalcin under acidic conditions. Decarboxylated osteocalcin at pH 2.0 retains the alpha-helix structure of native osteocalcin with three gamma-carboxyglutamic acid residues at neutral pH. This implies that decarboxylated osteocalcin is stable under an acidic environment in bone. In addition, site-directed mutagenesis revealed that Glu17 and Glu21 are important for the adiponectin-inducing activity of decarboxylated osteocalcin. These findings suggest that the receptor of decarboxylated osteocalcin responds to the negative charge in helix 1 of osteocalcin. | |||
Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin-inducing activity.,Mizuguchi M, Yokoyama T, Otani T, Kuribara S, Nabeshima Y, Obita T, Hirata M, Kawano K FEBS Lett. 2023 Jun;597(11):1479-1488. doi: 10.1002/1873-3468.14618. Epub 2023 , Apr 4. PMID:36976525<ref>PMID:36976525</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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== References == | |||
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