1rpq: Difference between revisions

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[[Image:1rpq.gif|left|200px]]<br />

[[Image:1rpq.gif|left|200px]]<br /><applet load="1rpq" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1rpq" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1rpq, resolution 3.00Å" />

'''High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from Phage Display'''<br />

==Overview==

Two structurally distinct classes of peptides were recently identified by, phage display that bind the high-affinity IgE receptor, FcepsilonRI, and, block IgE binding and subsequent receptor activation. Both classes adopt, highly stable structures in solution, one forming a beta hairpin, with the, other forming a helical "zeta" structure. Despite these differences, the, two classes bind competitively to the same site on the receptor., Structural analyses of both peptide-receptor complexes by NMR spectroscopy, and/or X-ray crystallography reveal that the unrelated peptide scaffolds, have nevertheless converged to present a similar three-dimensional surface, to interact with FcepsilonRI and that their modes of interaction share a, key feature of the IgE-FcepsilonRI complex, the proline/tryptophan, sandwich.

Two structurally distinct classes of peptides were recently identified by phage display that bind the high-affinity IgE receptor, FcepsilonRI, and block IgE binding and subsequent receptor activation. Both classes adopt highly stable structures in solution, one forming a beta hairpin, with the other forming a helical "zeta" structure. Despite these differences, the two classes bind competitively to the same site on the receptor. Structural analyses of both peptide-receptor complexes by NMR spectroscopy and/or X-ray crystallography reveal that the unrelated peptide scaffolds have nevertheless converged to present a similar three-dimensional surface to interact with FcepsilonRI and that their modes of interaction share a key feature of the IgE-FcepsilonRI complex, the proline/tryptophan sandwich.

==About this Structure==

1RPQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NDG, SO4 and CIT as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1RPQ OCA].

1RPQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDG:'>NDG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=CIT:'>CIT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPQ OCA].

==Reference==

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[[Category: Single protein]]

[[Category: Eigenbrot, C.]]

[[Category: Fairbrother, W.J.]]

[[Category: Fairbrother, W J.]]

[[Category: Lowman, H.B.]]

[[Category: Lowman, H B.]]

[[Category: Nakamura, G.R.]]

[[Category: Nakamura, G R.]]

[[Category: Reynolds, M.E.]]

[[Category: Reynolds, M E.]]

[[Category: Stamos, J.]]

[[Category: Starovasnik, M.A.]]

[[Category: Starovasnik, M A.]]

[[Category: Yin, J.P.]]

[[Category: Yin, J P.]]

[[Category: CIT]]

[[Category: NDG]]

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[[Category: receptor/peptide complex]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 19~~:06:~~16 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:53:17 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1rpq.gif|left|200px]]<br />
+[[Image:1rpq.gif|left|200px]]<br /><applet load="1rpq" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1rpq" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1rpq, resolution 3.00&Aring;" />
 '''High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from Phage Display'''<br />
 ==Overview==
-Two structurally distinct classes of peptides were recently identified by, phage display that bind the high-affinity IgE receptor, FcepsilonRI, and, block IgE binding and subsequent receptor activation. Both classes adopt, highly stable structures in solution, one forming a beta hairpin, with the, other forming a helical "zeta" structure. Despite these differences, the, two classes bind competitively to the same site on the receptor., Structural analyses of both peptide-receptor complexes by NMR spectroscopy, and/or X-ray crystallography reveal that the unrelated peptide scaffolds, have nevertheless converged to present a similar three-dimensional surface, to interact with FcepsilonRI and that their modes of interaction share a, key feature of the IgE-FcepsilonRI complex, the proline/tryptophan, sandwich.
+Two structurally distinct classes of peptides were recently identified by phage display that bind the high-affinity IgE receptor, FcepsilonRI, and block IgE binding and subsequent receptor activation. Both classes adopt highly stable structures in solution, one forming a beta hairpin, with the other forming a helical "zeta" structure. Despite these differences, the two classes bind competitively to the same site on the receptor. Structural analyses of both peptide-receptor complexes by NMR spectroscopy and/or X-ray crystallography reveal that the unrelated peptide scaffolds have nevertheless converged to present a similar three-dimensional surface to interact with FcepsilonRI and that their modes of interaction share a key feature of the IgE-FcepsilonRI complex, the proline/tryptophan sandwich.
 ==About this Structure==
-RPQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NDG, SO4 and CIT as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RPQ OCA].
+RPQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDG:'>NDG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=CIT:'>CIT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPQ OCA].
 ==Reference==
@@ Line 15: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Eigenbrot, C.]]
-[[Category: Fairbrother, W.J.]]
+[[Category: Fairbrother, W J.]]
-[[Category: Lowman, H.B.]]
+[[Category: Lowman, H B.]]
-[[Category: Nakamura, G.R.]]
+[[Category: Nakamura, G R.]]
-[[Category: Reynolds, M.E.]]
+[[Category: Reynolds, M E.]]
 [[Category: Stamos, J.]]
-[[Category: Starovasnik, M.A.]]
+[[Category: Starovasnik, M A.]]
-[[Category: Yin, J.P.]]
+[[Category: Yin, J P.]]
 [[Category: CIT]]
 [[Category: NDG]]
@@ Line 27: / Line 26: @@
 [[Category: receptor/peptide complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:06:16 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:53:17 2008''