1pww: Difference between revisions

Line 1:

[[Image:1pww.~~jpg~~|left|200px]]

[[Image:1pww.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.~~'''~~

===Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.===

~~==Overview==~~

<!--

~~Recent events have created an urgent need for new therapeutic strategies~~ to ~~treat anthrax. We have applied a mixture-based peptide library approach to rapidly determine~~ the ~~optimal peptide substrate for the anthrax lethal factor~~ (LF), ~~a metalloproteinase with an important role in the pathogenesis of~~ the ~~disease~~. ~~Using this approach we have identified peptide analogs that inhibit the enzyme in vitro and that protect cultured macrophages from LF~~-~~mediated cytolysis. The crystal structures of LF bound to an optimized peptide substrate and to peptide~~-~~based inhibitors provide a rationale for the observed selectivity and may be exploited in the design of future generations of LF inhibitors.~~

The line below this paragraph, {{ABSTRACT_PUBMED_14718924}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14718924 is the PubMed ID number.

-->

==About this Structure==

Line 27:

Line 31:

[[Category: Anthrax toxin]]

[[Category: Optimised peptide substrate]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:34:49 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:50:50 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1pww.jpg|left|200px]]
+{{Seed}}
+[[Image:1pww.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1pww|  PDB=1pww  |  SCENE=  }}
-'''Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.'''
+===Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.===
-==Overview==
+<!--
-Recent events have created an urgent need for new therapeutic strategies to treat anthrax. We have applied a mixture-based peptide library approach to rapidly determine the optimal peptide substrate for the anthrax lethal factor (LF), a metalloproteinase with an important role in the pathogenesis of the disease. Using this approach we have identified peptide analogs that inhibit the enzyme in vitro and that protect cultured macrophages from LF-mediated cytolysis. The crystal structures of LF bound to an optimized peptide substrate and to peptide-based inhibitors provide a rationale for the observed selectivity and may be exploited in the design of future generations of LF inhibitors.
+The line below this paragraph, {{ABSTRACT_PUBMED_14718924}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14718924 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14718924}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Anthrax toxin]]
 [[Category: Optimised peptide substrate]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:34:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:50:50 2008''