1pwv: Difference between revisions

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[[Image:1pwv.~~jpg~~|left|200px]]

[[Image:1pwv.png|left|200px]]

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~~'''~~Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.~~'''~~

===Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.===

~~==Overview==~~

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~~Recent events have created an urgent need for new therapeutic strategies~~ to ~~treat anthrax. We have applied a mixture-based peptide library approach to rapidly determine~~ the ~~optimal peptide substrate for the anthrax lethal factor~~ (LF), ~~a metalloproteinase with an important role in the pathogenesis of~~ the ~~disease~~. ~~Using this approach we have identified peptide analogs that inhibit the enzyme in vitro and that protect cultured macrophages from LF~~-~~mediated cytolysis. The crystal structures of LF bound to an optimized peptide substrate and to peptide~~-~~based inhibitors provide a rationale for the observed selectivity and may be exploited in the design of future generations of LF inhibitors.~~

The line below this paragraph, {{ABSTRACT_PUBMED_14718924}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14718924 is the PubMed ID number.

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==About this Structure==

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[[Category: Lethal factor]]

[[Category: Optimised peptide substrate]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3~~ 05:34:51 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:29:08 2008''

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-[[Image:1pwv.jpg|left|200px]]
+{{Seed}}
+[[Image:1pwv.png|left|200px]]
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 {{STRUCTURE_1pwv|  PDB=1pwv  |  SCENE=  }}
-'''Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.'''
+===Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.===
-==Overview==
+<!--
-Recent events have created an urgent need for new therapeutic strategies to treat anthrax. We have applied a mixture-based peptide library approach to rapidly determine the optimal peptide substrate for the anthrax lethal factor (LF), a metalloproteinase with an important role in the pathogenesis of the disease. Using this approach we have identified peptide analogs that inhibit the enzyme in vitro and that protect cultured macrophages from LF-mediated cytolysis. The crystal structures of LF bound to an optimized peptide substrate and to peptide-based inhibitors provide a rationale for the observed selectivity and may be exploited in the design of future generations of LF inhibitors.
+The line below this paragraph, {{ABSTRACT_PUBMED_14718924}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14718924 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14718924}}
 ==About this Structure==
@@ Line 28: / Line 32: @@
 [[Category: Lethal factor]]
 [[Category: Optimised peptide substrate]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:34:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:29:08 2008''