1pxd: Difference between revisions

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[[Image:1pxd.gif|left|200px]]
{{Seed}}
[[Image:1pxd.png|left|200px]]


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{{STRUCTURE_1pxd|  PDB=1pxd  |  SCENE=  }}  
{{STRUCTURE_1pxd|  PDB=1pxd  |  SCENE=  }}  


'''Crystal structure of the complex of jacalin with meso-tetrasulphonatophenylporphyrin.'''
===Crystal structure of the complex of jacalin with meso-tetrasulphonatophenylporphyrin.===




==Overview==
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The crystal structure of the complex of meso-tetrasulfonatophenylporphyrin (H(2)TPPS) with jack fruit (Artocarpus integriflora) agglutinin (jacalin) has been determined at 1.8 A resolution. A porphyrin pair is sandwiched between two symmetry-related jacalin monomers in the crystal, leading to a cross-linking network of protein molecules. Apart from the stacking interactions, H(2)TPPS also forms hydrogen bonds, some involving water bridges, with jacalin at the carbohydrate-binding site. The residues that are involved in rendering galactopyranoside specificity to jacalin undergo conformational adjustments in order to accommodate the H(2)TPPS molecule. The water molecules at the carbohydrate-binding site of jacalin cement the jacalin-porphyrin interactions, optimizing their complementarity. Interactions of porphyrin with jacalin are relatively weak compared with those observed between galactopyranoside and jacalin, perhaps because the former largely involves water-mediated hydrogen bonds. While H(2)TPPS binds to jacalin at the carbohydrate-binding site as in the case of ConA, its mode of interaction with jacalin is very different. H(2)TPPS does not enter the carbohydrate-binding cavity of jacalin. Instead, it sits over the binding site. While the porphyrin binding is mediated by replicating the hydrogen-bonding network of mannopyranoside through the sulfonate atoms in the case of ConA, the plasticity associated with the carbohydrate-binding site accommodates the pluripotent porphyrin molecule in the case of jacalin through an entirely different set of interactions.
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{{ABSTRACT_PUBMED_14747704}}


==About this Structure==
==About this Structure==
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[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Porphyrin]]
[[Category: Porphyrin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:35:54 2008''
 
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Revision as of 00:06, 29 July 2008

File:1pxd.png

Template:STRUCTURE 1pxd

Crystal structure of the complex of jacalin with meso-tetrasulphonatophenylporphyrin.

Template:ABSTRACT PUBMED 14747704

About this Structure

1PXD is a Protein complex structure of sequences from Artocarpus integer. Full crystallographic information is available from OCA.

Reference

Porphyrin binding to jacalin is facilitated by the inherent plasticity of the carbohydrate-binding site: novel mode of lectin-ligand interaction., Goel M, Anuradha P, Kaur KJ, Maiya BG, Swamy MJ, Salunke DM, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):281-8. Epub 2004, Jan 23. PMID:14747704

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