1pxe: Difference between revisions

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[[Image:1pxe.gif|left|200px]]
{{Seed}}
[[Image:1pxe.png|left|200px]]


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{{STRUCTURE_1pxe|  PDB=1pxe  |  SCENE=  }}  
{{STRUCTURE_1pxe|  PDB=1pxe  |  SCENE=  }}  


'''Solution Structure of a CCHHC Domain of Neural Zinc Finger Factor-1'''
===Solution Structure of a CCHHC Domain of Neural Zinc Finger Factor-1===




==Overview==
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The structure of a CCHHC zinc-binding domain from neural zinc finger factor-1 (NZF-1) has been determined in solution though the use of NMR methods. This domain is a member of a family of domains that have the Cys-X(4)-Cys-X(4)-His-X(7)-His-X(5)-Cys consensus sequence. The structure determination reveals a novel fold based around a zinc(II) ion coordinated to three Cys residues and the second of the two conserved His residues. The other His residue is stacked between the metal-coordinated His residue and a relatively conserved aromatic residue. Analysis of His to Gln sequence variants reveals that both His residues are required for the formation of a well-defined structure, but neither is required for high-affinity metal binding at a tetrahedral site. The structure suggests that a two-domain protein fragment and a double-stranded DNA binding site may interact with a common two-fold axis relating the two domains and the two half-sites of the DNA-inverted repeat.
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{{ABSTRACT_PUBMED_14744132}}


==About this Structure==
==About this Structure==
1PXE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXE OCA].  
1PXE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXE OCA].  


==Reference==
==Reference==
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[[Category: Dna binding domain]]
[[Category: Dna binding domain]]
[[Category: Neural zinc finger factor-1]]
[[Category: Neural zinc finger factor-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:27:26 2008''

Revision as of 05:27, 29 July 2008

File:1pxe.png

Template:STRUCTURE 1pxe

Solution Structure of a CCHHC Domain of Neural Zinc Finger Factor-1

Template:ABSTRACT PUBMED 14744132

About this Structure

1PXE is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Solution structure of a CCHHC domain of neural zinc finger factor-1 and its implications for DNA binding., Berkovits-Cymet HJ, Amann BT, Berg JM, Biochemistry. 2004 Feb 3;43(4):898-903. PMID:14744132

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