8vtt: Difference between revisions

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'''Unreleased structure'''


The entry 8vtt is ON HOLD  until Paper Publication
==Meis1 homeobox domain bound to neomycin fragment==
 
<StructureSection load='8vtt' size='340' side='right'caption='[[8vtt]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
Authors: Tomchick, D.R., Ahmed, M.S., Nguyen, N.U.N., Sadek, H.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8vtt]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VTT FirstGlance]. <br>
Description: Meis1 homeobox domain bound to neomycin fragment
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RIO:RIBOSTAMYCIN'>RIO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Sadek, H.A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vtt OCA], [https://pdbe.org/8vtt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vtt RCSB], [https://www.ebi.ac.uk/pdbsum/8vtt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vtt ProSAT]</span></td></tr>
[[Category: Nguyen, N.U.N]]
</table>
[[Category: Tomchick, D.R]]
== Disease ==
[[Category: Ahmed, M.S]]
[https://www.uniprot.org/uniprot/MEIS1_MOUSE MEIS1_MOUSE] Meis1 serves as a site of viral integration in 15% of the tumors arising in BXH-2 mice that develop myeloid leukemia as a result of the expression of an ecotropic murine leukemia virus.<ref>PMID:7565694</ref>
== Function ==
[https://www.uniprot.org/uniprot/MEIS1_MOUSE MEIS1_MOUSE] Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.<ref>PMID:12183364</ref> <ref>PMID:15882575</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ahmed MS]]
[[Category: Nguyen NUN]]
[[Category: Sadek HA]]
[[Category: Tomchick DR]]
Retrieved from "https://proteopedia.org/8vtt"