1pyt: Difference between revisions

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[[Image:1pyt.gif|left|200px]]
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{{STRUCTURE_1pyt|  PDB=1pyt  |  SCENE=  }}  
{{STRUCTURE_1pyt|  PDB=1pyt  |  SCENE=  }}  


'''TERNARY COMPLEX OF PROCARBOXYPEPTIDASE A, PROPROTEINASE E, AND CHYMOTRYPSINOGEN C'''
===TERNARY COMPLEX OF PROCARBOXYPEPTIDASE A, PROPROTEINASE E, AND CHYMOTRYPSINOGEN C===




==Overview==
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The metalloexozymogen procarboxypeptidase A is mainly secreted in ruminants as a ternary complex with zymogens of two serine endoproteinases, chymotrypsinogen C and proproteinase E. The bovine complex has been crystallized, and its molecular structure analysed and refined at 2.6 A resolution to an R factor of 0.198. In this heterotrimer, the activation segment of procarboxypeptidase A essentially clamps the other two subunits, which shield the activation sites of the former from tryptic attack. In contrast, the propeptides of both serine proproteinases are freely accessible to trypsin. This arrangement explains the sequential and delayed activation of the constituent zymogens. Procarboxypeptidase A is virtually identical to the homologous monomeric porcine form. Chymotrypsinogen C displays structural features characteristic for chymotrypsins as well as elastases, except for its activation domain; similar to bovine chymotrypsinogen A, its binding site is not properly formed, while its surface located activation segment is disordered. The proproteinase E structure is fully ordered and strikingly similar to active porcine elastase; its specificity pocket is occluded, while the activation segment is fixed to the molecular surface. This first structure of a native zymogen from the proteinase E/elastase family does not fundamentally differ from the serine proproteinases known so far.
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{{ABSTRACT_PUBMED_7556081}}


==About this Structure==
==About this Structure==
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[[Category: C-terminal peptidase]]
[[Category: C-terminal peptidase]]
[[Category: Serine proteinase]]
[[Category: Serine proteinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:39:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:51:02 2008''

Revision as of 13:51, 28 July 2008

File:1pyt.png

Template:STRUCTURE 1pyt

TERNARY COMPLEX OF PROCARBOXYPEPTIDASE A, PROPROTEINASE E, AND CHYMOTRYPSINOGEN C

Template:ABSTRACT PUBMED 7556081

About this Structure

1PYT is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C., Gomis-Ruth FX, Gomez M, Bode W, Huber R, Aviles FX, EMBO J. 1995 Sep 15;14(18):4387-94. PMID:7556081

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