1pzw: Difference between revisions

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[[Image:1pzw.~~gif~~|left|200px]]

[[Image:1pzw.png|left|200px]]

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~~'''~~Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone~~'''~~

===Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone===

~~==Overview==~~

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~~About one-third of~~ the ~~more than 300 C2H2 zinc finger proteins of Drosophila contain a conserved sequence motif,~~ the ~~zinc finger-associated domain~~ (~~ZAD)~~. ~~Genes that encode ZAD proteins are specific for and expanded in the genomes of insects~~. ~~Only three ZAD-encoding gene functions are established~~, ~~and the role of ZAD~~ is ~~unknown. Here we present~~ the ~~crystal structure of the ZAD of Grauzone (ZAD(Grau)), a Drosophila transcription factor that specifically controls the maternal Cdc20-like APC subunit Cortex~~. ~~ZAD forms an atypical treble~~-~~clef~~-like zinc-coordinating fold. Head-to-tail arrangement of two ZAD(Grau) molecules in the crystals suggests dimer formation, an observation supported by crosslinking and dynamic light scattering. The results indicate that ZAD provides a novel protein-protein interaction module that characterizes a large family of insect transcription factors.

The line below this paragraph, {{ABSTRACT_PUBMED_14604529}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14604529 is the PubMed ID number.

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==About this Structure==

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[[Category: X-ray crystallography]]

[[Category: Zad]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:41:44 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:57:36 2008''

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-[[Image:1pzw.gif|left|200px]]
+{{Seed}}
+[[Image:1pzw.png|left|200px]]
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 {{STRUCTURE_1pzw|  PDB=1pzw  |  SCENE=  }}
-'''Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone'''
+===Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone===
-==Overview==
+<!--
-About one-third of the more than 300 C2H2 zinc finger proteins of Drosophila contain a conserved sequence motif, the zinc finger-associated domain (ZAD). Genes that encode ZAD proteins are specific for and expanded in the genomes of insects. Only three ZAD-encoding gene functions are established, and the role of ZAD is unknown. Here we present the crystal structure of the ZAD of Grauzone (ZAD(Grau)), a Drosophila transcription factor that specifically controls the maternal Cdc20-like APC subunit Cortex. ZAD forms an atypical treble-clef-like zinc-coordinating fold. Head-to-tail arrangement of two ZAD(Grau) molecules in the crystals suggests dimer formation, an observation supported by crosslinking and dynamic light scattering. The results indicate that ZAD provides a novel protein-protein interaction module that characterizes a large family of insect transcription factors.
+The line below this paragraph, {{ABSTRACT_PUBMED_14604529}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14604529 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14604529}}
 ==About this Structure==
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 [[Category: X-ray crystallography]]
 [[Category: Zad]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:41:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:57:36 2008''