1q08: Difference between revisions

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[[Image:1q08.gif|left|200px]]
{{Seed}}
[[Image:1q08.png|left|200px]]


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{{STRUCTURE_1q08|  PDB=1q08  |  SCENE=  }}  
{{STRUCTURE_1q08|  PDB=1q08  |  SCENE=  }}  


'''Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator, at 1.9 A resolution (space group P212121)'''
===Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator, at 1.9 A resolution (space group P212121)===




==Overview==
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The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators. Thermodynamic calibration of CueR reveals a zeptomolar (10(-21) molar) sensitivity to free Cu+, which is far less than one atom per cell. Atomic details of this extraordinary sensitivity and selectivity for +1transition-metal ions are revealed by comparing the crystal structures of CueR and a Zn2+-sensing homolog, ZntR. An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding. This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
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{{ABSTRACT_PUBMED_12958362}}


==About this Structure==
==About this Structure==
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[[Category: Xue, Y.]]
[[Category: Xue, Y.]]
[[Category: Merr family transcriptional regulator]]
[[Category: Merr family transcriptional regulator]]
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