1q0g: Difference between revisions

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[[Image:1q0g.gif|left|200px]]
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[[Image:1q0g.png|left|200px]]


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{{STRUCTURE_1q0g|  PDB=1q0g  |  SCENE=  }}  
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'''Crystal structure of Ni-containing superoxide dismutase with Ni-ligation corresponding to the state after full x-ray-induced reduction'''
===Crystal structure of Ni-containing superoxide dismutase with Ni-ligation corresponding to the state after full x-ray-induced reduction===




==Overview==
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Superoxide dismutases (SODs, EC 1.15.1.1) are ubiquitous enzymes that efficiently catalyze the dismutation of superoxide radical anions to protect biological molecules from oxidative damage. The crystal structure of nickel-containing SOD (NiSOD) from Streptomyces seoulensis was determined for the resting, x-ray-reduced, and thiosulfate-reduced enzyme state. NiSOD is a homohexamer consisting of four-helix-bundle subunits. The catalytic center resides in the N-terminal active-site loop, where a Ni(III) ion is coordinated by the amino group of His-1, the amide group of Cys-2, two thiolate groups of Cys-2 and Cys-6, and the imidazolate of His-1 as axial ligand that is lost in the chemically reduced state as well as after x-ray-induced reduction. This structure represents a third class of SODs concerning the catalytic metal species, subunit structure, and oligomeric organization. It adds a member to the small number of Ni-metalloenzymes and contributes with its Ni(III) active site to the general understanding of Ni-related biochemistry. NiSOD is shown to occur also in bacteria other than Streptomyces and is predicted to be present in some cyanobacteria.
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{{ABSTRACT_PUBMED_15173586}}


==About this Structure==
==About this Structure==
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[[Category: Yim, Y I.]]
[[Category: Yim, Y I.]]
[[Category: Homohexamer of four-helix bundle]]
[[Category: Homohexamer of four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:24:27 2008''

Revision as of 03:24, 29 July 2008

File:1q0g.png

Template:STRUCTURE 1q0g

Crystal structure of Ni-containing superoxide dismutase with Ni-ligation corresponding to the state after full x-ray-induced reduction

Template:ABSTRACT PUBMED 15173586

About this Structure

1Q0G is a Single protein structure of sequence from Streptomyces seoulensis. Full crystallographic information is available from OCA.

Reference

Crystal structure of nickel-containing superoxide dismutase reveals another type of active site., Wuerges J, Lee JW, Yim YI, Yim HS, Kang SO, Djinovic Carugo K, Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8569-74. Epub 2004 Jun 1. PMID:15173586

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