1q0p: Difference between revisions

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[[Image:1q0p.gif|left|200px]]
{{Seed}}
[[Image:1q0p.png|left|200px]]


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{{STRUCTURE_1q0p|  PDB=1q0p  |  SCENE=  }}  
{{STRUCTURE_1q0p|  PDB=1q0p  |  SCENE=  }}  


'''A domain of Factor B'''
===A domain of Factor B===




==Overview==
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Complement factor B is a 90 kDa protein consisting of three domains: a three-module complement control protein, a von Willebrand factor A domain, and a C-terminal serine protease (SP) domain that adopts a default inactive (zymogen) conformation. The interaction between factor B and pathogen-bound C3b is mediated by its A domain, triggering a conformational change in factor B that ultimately creates the "C3 convertase" of the alternative complement pathway. We report the crystal structure of the A domain from factor B and show that it contains an integrin-like MIDAS motif that adopts the "open" conformation typical of integrin-ligand complexes, with an acidic residue (provided by a fortuitous crystal contact) completing the coordination of the metal ion. Modeling studies indicate that the factor B A domain can also adopt the closed conformation, supporting the hypothesis that an "integrin-like switch" is conserved in complement proteins and perhaps in 60 other A domains found within the human proteome.
The line below this paragraph, {{ABSTRACT_PUBMED_15016353}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15016353 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15016353}}


==Disease==
==Disease==
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[[Category: Mac-1]]
[[Category: Mac-1]]
[[Category: Von willebrand factor]]
[[Category: Von willebrand factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:43:21 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:46:26 2008''

Revision as of 13:46, 28 July 2008

File:1q0p.png

Template:STRUCTURE 1q0p

A domain of Factor B

Template:ABSTRACT PUBMED 15016353

Disease

Known disease associated with this structure: Macular degeneration, age-related, reduced risk of OMIM:[138470]

About this Structure

1Q0P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation., Bhattacharya AA, Lupher ML Jr, Staunton DE, Liddington RC, Structure. 2004 Mar;12(3):371-8. PMID:15016353

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