1q2i: Difference between revisions

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[[Image:1q2i.jpg|left|200px]]
{{Seed}}
[[Image:1q2i.png|left|200px]]


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{{STRUCTURE_1q2i|  PDB=1q2i  |  SCENE=  }}  
{{STRUCTURE_1q2i|  PDB=1q2i  |  SCENE=  }}  


'''NMR SOLUTION STRUCTURE OF A PEPTIDE FROM THE MDM-2 BINDING DOMAIN OF THE P53 PROTEIN THAT IS SELECTIVELY CYTOTOXIC TO CANCER CELLS'''
===NMR SOLUTION STRUCTURE OF A PEPTIDE FROM THE MDM-2 BINDING DOMAIN OF THE P53 PROTEIN THAT IS SELECTIVELY CYTOTOXIC TO CANCER CELLS===




==Overview==
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We have recently found that a peptide from the mdm-2 binding domain of the p53 protein induced rapid membranolytic necrosis of a variety of different human cancer cell lines. To determine the role of solution structure in this peptide's selective and rapid tumor membrane disruptive behavior, we have performed two-dimensional NMR on a 32-residue sequence called PNC-27, in both an aqueous cytosolic-like and a mixed organic membrane-mimetic solution environment. In an aqueous milieu, PNC-27 contains three alpha-helical domains connected by loop structures, forming an S shape, and another similar structure with less helical structure. In a solution environment simulating a membrane, the helical domains found in water increase in length, forming three classes of structures, all of which form a U-shaped helix-coil-helix ensemble. In both solvent systems, this peptide forms amphipathic structures such that its hydrophobic residues coalesce on one face while the polar residues aggregate on the opposite face. The ability to form these unique structures in these two solution environments may allow the PNC-27 peptide to selectively and rapidly disrupt cancer cell membranes.
The line below this paragraph, {{ABSTRACT_PUBMED_14967026}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 14967026 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14967026}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2I OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2I OCA].  


==Reference==
==Reference==
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[[Category: P53 protein]]
[[Category: P53 protein]]
[[Category: Penetratin]]
[[Category: Penetratin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:47:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:15:02 2008''

Revision as of 21:15, 27 July 2008

File:1q2i.png

Template:STRUCTURE 1q2i

NMR SOLUTION STRUCTURE OF A PEPTIDE FROM THE MDM-2 BINDING DOMAIN OF THE P53 PROTEIN THAT IS SELECTIVELY CYTOTOXIC TO CANCER CELLS

Template:ABSTRACT PUBMED 14967026

About this Structure

Full experimental information is available from OCA.

Reference

NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells., Rosal R, Pincus MR, Brandt-Rauf PW, Fine RL, Michl J, Wang H, Biochemistry. 2004 Feb 24;43(7):1854-61. PMID:14967026

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