1s3a: Difference between revisions

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[[Image:1s3a.gif|left|200px]]<br />

[[Image:1s3a.gif|left|200px]]<br /><applet load="1s3a" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1s3a" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1s3a" />

'''NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)'''<br />

==Overview==

Subunit B8 from ubiquinone oxidoreductase (complex I) (CI-B8) is one of, several nuclear-encoded supernumerary subunits that are not present in, bacterial complex I. Its solution structure shows a thioredoxin fold with, highest similarities to the human thioredoxin mutant C73S and thioredoxin, 2 from Anabeana sp. Interestingly, these proteins contain active sites in, the same area, where the disulfide bond of oxidized CI-B8 is located. The, redox potential of this disulfide bond is -251.6 mV, comparing well to, that of disulfides in other thioredoxin-like proteins. Analysis of the, structure reveals a surface area that is exclusively composed of highly, conserved residues and thus most likely a subunit interaction site within, complex I.

Subunit B8 from ubiquinone oxidoreductase (complex I) (CI-B8) is one of several nuclear-encoded supernumerary subunits that are not present in bacterial complex I. Its solution structure shows a thioredoxin fold with highest similarities to the human thioredoxin mutant C73S and thioredoxin 2 from Anabeana sp. Interestingly, these proteins contain active sites in the same area, where the disulfide bond of oxidized CI-B8 is located. The redox potential of this disulfide bond is -251.6 mV, comparing well to that of disulfides in other thioredoxin-like proteins. Analysis of the structure reveals a surface area that is exclusively composed of highly conserved residues and thus most likely a subunit interaction site within complex I.

==About this Structure==

1S3A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1S3A OCA].

1S3A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3A OCA].

==Reference==

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[[Category: nmr]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 19~~:10:~~01 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:57:27 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1s3a.gif|left|200px]]<br />
+[[Image:1s3a.gif|left|200px]]<br /><applet load="1s3a" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1s3a" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1s3a" />
 '''NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)'''<br />
 ==Overview==
-Subunit B8 from ubiquinone oxidoreductase (complex I) (CI-B8) is one of, several nuclear-encoded supernumerary subunits that are not present in, bacterial complex I. Its solution structure shows a thioredoxin fold with, highest similarities to the human thioredoxin mutant C73S and thioredoxin, 2 from Anabeana sp. Interestingly, these proteins contain active sites in, the same area, where the disulfide bond of oxidized CI-B8 is located. The, redox potential of this disulfide bond is -251.6 mV, comparing well to, that of disulfides in other thioredoxin-like proteins. Analysis of the, structure reveals a surface area that is exclusively composed of highly, conserved residues and thus most likely a subunit interaction site within, complex I.
+Subunit B8 from ubiquinone oxidoreductase (complex I) (CI-B8) is one of several nuclear-encoded supernumerary subunits that are not present in bacterial complex I. Its solution structure shows a thioredoxin fold with highest similarities to the human thioredoxin mutant C73S and thioredoxin 2 from Anabeana sp. Interestingly, these proteins contain active sites in the same area, where the disulfide bond of oxidized CI-B8 is located. The redox potential of this disulfide bond is -251.6 mV, comparing well to that of disulfides in other thioredoxin-like proteins. Analysis of the structure reveals a surface area that is exclusively composed of highly conserved residues and thus most likely a subunit interaction site within complex I.
 ==About this Structure==
-S3A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1S3A OCA].
+S3A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3A OCA].
 ==Reference==
@@ Line 24: / Line 23: @@
 [[Category: nmr]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:10:01 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:57:27 2008''