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| [[Image:1q74.gif|left|200px]] | | {{Seed}} |
| | [[Image:1q74.png|left|200px]] |
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| {{STRUCTURE_1q74| PDB=1q74 | SCENE= }} | | {{STRUCTURE_1q74| PDB=1q74 | SCENE= }} |
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| '''The Crystal Structure of 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB)'''
| | ===The Crystal Structure of 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB)=== |
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| ==Overview==
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| The C2-symmetric vinyl sulfoxide, trans-2-methylene-1,3-dithiolane 1,3-dioxide, was found to react with a range of 3-oxidopyridinium betaines (bearing different substituents on nitrogen) in high yield and with total diastereoselectivity. A 2.3:1 mixture of regioisomers was formed with all of the 3-oxidopyridinium betaines but the ratio was found to change over prolonged periods of time due to reversibility of the minor regioisomer. 3-Oxidopyridinium betaines bearing methyl substituents at either the 2- or 6-position were also tested in the cycloaddition process. Improved regioselectivity (8:1) and again high diastereoselectivity were observed with the betaine having an additional substituent at the 2-position, but with betaines having a substituent in the 6-position although high regioselectivity was observed (9.9:1), the major isomer was formed with low diastereoselectivity (5.5:4.4). The origin of the regio- and diastereo-selectivity with all the betaines is discussed. Finally, the C2-symmetric vinyl sulfoxide, trans-2-methylene-1,3-dithiolane 1,3-dioxide was reacted with an oxidopyrylium betaine in moderate yield. Good regioselectivity and moderate diastereoselectivity were observed. | | The line below this paragraph, {{ABSTRACT_PUBMED_12945769}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12945769 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12945769}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Tbsgc]] | | [[Category: Tbsgc]] |
| [[Category: Zinc aminohydrolase]] | | [[Category: Zinc aminohydrolase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:57:02 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:55:45 2008'' |
