1sac: Difference between revisions
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'''THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT'''<br /> | '''THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT'''<br /> | ||
==Overview== | ==Overview== | ||
The three-dimensional structure of pentameric human serum amyloid P | The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1SAC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1SAC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAC OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Blundell, T | [[Category: Blundell, T L.]] | ||
[[Category: Emsley, J.]] | [[Category: Emsley, J.]] | ||
[[Category: Hara, B | [[Category: Hara, B P.O.]] | ||
[[Category: Oliva, G.]] | [[Category: Oliva, G.]] | ||
[[Category: Pepys, M | [[Category: Pepys, M B.]] | ||
[[Category: Srinivasan, N.]] | [[Category: Srinivasan, N.]] | ||
[[Category: Tickle, I | [[Category: Tickle, I J.]] | ||
[[Category: White, H | [[Category: White, H E.]] | ||
[[Category: Wood, S | [[Category: Wood, S P.]] | ||
[[Category: ACY]] | [[Category: ACY]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: amyloid protein]] | [[Category: amyloid protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:59:27 2008'' | ||
Revision as of 12:59, 21 February 2008
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THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT
Overview
The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.
Disease
Known disease associated with this structure: Amyloidosis, secondary, susceptibility to OMIM:[104770]
About this Structure
1SAC is a Single protein structure of sequence from Homo sapiens with CA and ACY as ligands. Full crystallographic information is available from OCA.
Reference
Structure of pentameric human serum amyloid P component., Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP, Nature. 1994 Jan 27;367(6461):338-45. PMID:8114934
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