1qb9: Difference between revisions

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[[Image:1qb9.~~jpg~~|left|200px]]

[[Image:1qb9.png|left|200px]]

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~~'''~~BOVINE TRYPSIN 7-[[2-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-9H-CARBOZOL-9-YL] METHYL]NAPHTHALENE-2-CARBOXIMIDAMIDE (ZK-806450) COMPLEX~~'''~~

===BOVINE TRYPSIN 7-[[2-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-9H-CARBOZOL-9-YL] METHYL]NAPHTHALENE-2-CARBOXIMIDAMIDE (ZK-806450) COMPLEX===

~~==Overview==~~

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~~Factor Xa is a serine protease which activates thrombin (factor IIa) and plays a key regulatory role in the blood-coagulation cascade. Factor Xa is~~, ~~therefore~~, ~~an important target for~~ the design of anti-thrombotics. Both factor Xa and thrombin share sequence and structural homology with trypsin. As part of a factor Xa inhibitor-design program, a number of factor Xa inhibitors were crystallographically studied complexed to ~~bovine trypsin~~. ~~The structures of one diaryl benzimidazole, one diaryl carbazole and three diaryloxypyridines are described~~. ~~All five compounds bind to trypsin in an extended conformation~~, ~~with an amidinoaryl group in~~ the ~~S1 pocket and a second basic/hydrophobic moiety bound in the S4 pocket~~. ~~These binding modes all bear a resemblance to the reported binding mode of DX~~-~~9065a in bovine trypsin and human factor Xa.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10417407}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10417407 is the PubMed ID number.

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==About this Structure==

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[[Category: S1 pocket]]

[[Category: Serine proteinase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:05:40 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:12:06 2008''

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-[[Image:1qb9.jpg|left|200px]]
+{{Seed}}
+[[Image:1qb9.png|left|200px]]
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 {{STRUCTURE_1qb9|  PDB=1qb9  |  SCENE=  }}
-'''BOVINE TRYPSIN 7-[[2-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-9H-CARBOZOL-9-YL] METHYL]NAPHTHALENE-2-CARBOXIMIDAMIDE (ZK-806450) COMPLEX'''
+===BOVINE TRYPSIN 7-[[2-[[1-(1-IMINOETHYL)PIPERIDIN-4-YL]OXY]-9H-CARBOZOL-9-YL] METHYL]NAPHTHALENE-2-CARBOXIMIDAMIDE (ZK-806450) COMPLEX===
-==Overview==
+<!--
-Factor Xa is a serine protease which activates thrombin (factor IIa) and plays a key regulatory role in the blood-coagulation cascade. Factor Xa is, therefore, an important target for the design of anti-thrombotics. Both factor Xa and thrombin share sequence and structural homology with trypsin. As part of a factor Xa inhibitor-design program, a number of factor Xa inhibitors were crystallographically studied complexed to bovine trypsin. The structures of one diaryl benzimidazole, one diaryl carbazole and three diaryloxypyridines are described. All five compounds bind to trypsin in an extended conformation, with an amidinoaryl group in the S1 pocket and a second basic/hydrophobic moiety bound in the S4 pocket. These binding modes all bear a resemblance to the reported binding mode of DX-9065a in bovine trypsin and human factor Xa.
+The line below this paragraph, {{ABSTRACT_PUBMED_10417407}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10417407 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10417407}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: S1 pocket]]
 [[Category: Serine proteinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:05:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:12:06 2008''