8g5b: Difference between revisions

Latest revision as of 09:38, 17 October 2024

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 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g5b OCA], [https://pdbe.org/8g5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g5b RCSB], [https://www.ebi.ac.uk/pdbsum/8g5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g5b ProSAT]</span></td></tr>
 </table>
-== Function ==
-[https://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
 __TOC__
 </StructureSection>