1qet: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:1qet.gif|left|200px]]
{{Seed}}
[[Image:1qet.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1qet|  PDB=1qet  |  SCENE=  }}  
{{STRUCTURE_1qet|  PDB=1qet  |  SCENE=  }}  


'''TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES'''
===TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES===




==Overview==
<!--
The symmetric, tandem GU mismatch motifs, and , which only differ in the mismatch order, have an average difference in thermodynamic stability of 2 kcal/mol at 37 degrees C. Thermodynamic studies of duplexes containing these motifs indicate the effect is largely localized to the mismatches and adjacent base pairs. The three-dimensional structures of two representative duplexes, (rGGAGUUCC)2 and (rGGAUGUCC)2, were determined by two-dimensional NMR and a simulated annealing protocol. Local deviations are similar to other intrahelical GU mismatches with little effect on backbone torsion angles and a slight overtwisting between the base pair 5' of the G of the mismatch and the mismatch itself. Comparisons of the resulting stacking patterns along with electrostatic potential maps suggest that interactions between highly negative electrostatic regions between base pairs may play a role in the observed thermodynamic differences.
The line below this paragraph, {{ABSTRACT_PUBMED_9201950}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9201950 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_9201950}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QET OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QET OCA].  


==Reference==
==Reference==
Line 26: Line 30:
[[Category: G:u mismatch]]
[[Category: G:u mismatch]]
[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:10:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:37:05 2008''

Revision as of 01:37, 29 July 2008

File:1qet.png

Template:STRUCTURE 1qet

TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES

Template:ABSTRACT PUBMED 9201950

About this Structure

Full experimental information is available from OCA.

Reference

Investigation of the structural basis for thermodynamic stabilities of tandem GU wobble pairs: NMR structures of (rGGAGUUCC)2 and (rGGAUGUCC)2., McDowell JA, He L, Chen X, Turner DH, Biochemistry. 1997 Jul 1;36(26):8030-8. PMID:9201950

Page seeded by OCA on Tue Jul 29 04:37:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1qet&oldid=727242"