1qf4: Difference between revisions

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[[Image:1qf4.jpg|left|200px]]
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{{STRUCTURE_1qf4|  PDB=1qf4  |  SCENE=  }}  
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'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''
===DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE===




==Overview==
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Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
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{{ABSTRACT_PUBMED_10556888}}


==About this Structure==
==About this Structure==
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[[Category: Purine biosynthesis]]
[[Category: Purine biosynthesis]]
[[Category: Synthetase]]
[[Category: Synthetase]]
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Revision as of 00:32, 28 July 2008

File:1qf4.png

Template:STRUCTURE 1qf4

DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE

Template:ABSTRACT PUBMED 10556888

About this Structure

1QF4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:10556888

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