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| [[Image:1qfb.jpg|left|200px]] | | {{Seed}} |
| | [[Image:1qfb.png|left|200px]] |
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| {{STRUCTURE_1qfb| PDB=1qfb | SCENE= }} | | {{STRUCTURE_1qfb| PDB=1qfb | SCENE= }} |
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| '''THE CYCLIC PEPTIDE CONTRYPHAN-R FROM CONUS RADIATUS'''
| | ===THE CYCLIC PEPTIDE CONTRYPHAN-R FROM CONUS RADIATUS=== |
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| ==Overview==
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| Contryphan-R is a disulfide-constrained octapeptide containing a D-tryptophan that was isolated recently from venom of the cone shell Conus radiatus. The polypeptide is present in two forms in solution due to cis-trans isomerization at hydroxyproline 3. The solution structure of the major form of this unusual polypeptide, determined from NMR data, consists of a well-defined fold containing a non-hydrogen-bonded chain reversal from Gly1 to Glu5, which includes a cis-hydroxyproline and a D-Trp, and a type I beta-turn from Glu5 to Cys8. The presence of a putative salt bridge between the Glu5 carboxyl group and the N-terminal ammonium group is investigated by using various solvation models during energy minimization and is compared with the results of a pH titration. A comparison of the structure of contryphan-R with other cyclic peptide structures highlights some of the key structural determinants of these peptides and suggests that the contryphan-R fold could be exploited as a scaffold onto which unrelated protein binding surfaces could be grafted. Comparison with small disulfide-bridged loops in larger proteins shows that contryphan-R is similar to a commonly occurring loop structure found in proteins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_10471307}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10471307 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10471307}} |
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| ==About this Structure== | | ==About this Structure== |
| 1QFB is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFB OCA]. | | 1QFB is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFB OCA]. |
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| ==Reference== | | ==Reference== |
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| [[Category: Stiff-tail syndrome]] | | [[Category: Stiff-tail syndrome]] |
| [[Category: Venom duct peptide]] | | [[Category: Venom duct peptide]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:11:53 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:10:36 2008'' |
