1qfj: Difference between revisions

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[[Image:1qfj.gif|left|200px]]
{{Seed}}
[[Image:1qfj.png|left|200px]]


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{{STRUCTURE_1qfj|  PDB=1qfj  |  SCENE=  }}  
{{STRUCTURE_1qfj|  PDB=1qfj  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF NAD(P)H:FLAVIN OXIDOREDUCTASE FROM ESCHERICHIA COLI'''
===CRYSTAL STRUCTURE OF NAD(P)H:FLAVIN OXIDOREDUCTASE FROM ESCHERICHIA COLI===




==Overview==
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Flavin reductases use flavins as substrates and are distinct from flavoenzymes which have tightly bound flavins. The reduced flavin can serve to reduce ferric complexes and iron proteins. In Escherichia coli, reactivation of ribonucleotide reductase is achieved by reduced flavins produced by flavin reductase. The crystal structure of E. coli flavin reductase reveals that the enzyme structure is similar to the structures of the ferredoxin reductase family of flavoproteins despite very low sequence similarities. The main difference between flavin reductase and structurally related flavoproteins is that there is no binding site for the AMP moiety of FAD. The direction of the helix in the flavin binding domain, corresponding to the phosphate binding helix in the flavoproteins, is also slightly different and less suitable for phosphate binding. Interactions for flavin substrates are instead provided by a hydrophobic isoalloxazine binding site that also contains a serine and a threonine, which form hydrogen bonds to the isoalloxazine of bound riboflavin in a substrate complex.
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{{ABSTRACT_PUBMED_10353815}}


==About this Structure==
==About this Structure==
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[[Category: Flavin reductase]]
[[Category: Flavin reductase]]
[[Category: Riboflavin]]
[[Category: Riboflavin]]
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Revision as of 01:53, 29 July 2008

File:1qfj.png

Template:STRUCTURE 1qfj

CRYSTAL STRUCTURE OF NAD(P)H:FLAVIN OXIDOREDUCTASE FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 10353815

About this Structure

1QFJ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of NAD(P)H:flavin oxidoreductase from Escherichia coli., Ingelman M, Ramaswamy S, Niviere V, Fontecave M, Eklund H, Biochemistry. 1999 Jun 1;38(22):7040-9. PMID:10353815

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