1qix: Difference between revisions

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[[Image:1qix.jpg|left|200px]]
{{Seed}}
[[Image:1qix.png|left|200px]]


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{{STRUCTURE_1qix|  PDB=1qix  |  SCENE=  }}  
{{STRUCTURE_1qix|  PDB=1qix  |  SCENE=  }}  


'''PORCINE PANCREATIC ELASTASE COMPLEXED WITH HUMAN BETA-CASOMORPHIN-7'''
===PORCINE PANCREATIC ELASTASE COMPLEXED WITH HUMAN BETA-CASOMORPHIN-7===




==Overview==
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Mass spectrometric screening reveals that an unmodified natural heptapeptide--human beta-casomorphin-7, an internal sequence of human beta-casein that possesses opioid-like activity--reacts with porcine pancreatic elastase to form an unusually stable acyl-enzyme complex at low pH. X-ray crystallographic analysis (to 1.9 A resolution) at pH 5 shows continuous electron density linking the C-terminal isoleucine of beta-casomorphin-7 to Ser 195 through an ester bond. The structure reveals a well defined water molecule (Wat 317), equidistant between the carbon of the ester carbonyl and N epsilon 2 of His 57. Deprotonation of Wat 317 will produce a hydroxide ion positioned to attack the ester carbonyl through the favoured Burgi-Dunitz trajectory.
The line below this paragraph, {{ABSTRACT_PUBMED_9187653}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9187653 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9187653}}


==About this Structure==
==About this Structure==
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[[Category: Schofield, C J.]]
[[Category: Schofield, C J.]]
[[Category: Wilmouth, R C.]]
[[Category: Wilmouth, R C.]]
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