1snk: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /> <applet load="1snk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1snk, resolution 2.40Å" /> '''Cathepsin K complex... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1snk.gif|left|200px]]<br /> | [[Image:1snk.gif|left|200px]]<br /><applet load="1snk" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1snk" size=" | |||
caption="1snk, resolution 2.40Å" /> | caption="1snk, resolution 2.40Å" /> | ||
'''Cathepsin K complexed with carbamate derivatized norleucine aldehyde'''<br /> | '''Cathepsin K complexed with carbamate derivatized norleucine aldehyde'''<br /> | ||
==Overview== | ==Overview== | ||
The synthesis and biological activity of a series of aldehyde inhibitors | The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S2 and S3 subsites with a series of carbamate derivatized norleucine aldehydes substituted at the P2 and P3 positions afforded analogs with cathepsin K IC50s between 600 nM and 130 pM. | ||
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
1SNK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and MYE as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http:// | 1SNK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=MYE:'>MYE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNK OCA]. | ||
==Reference== | ==Reference== | ||
| Line 18: | Line 17: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Boros, E | [[Category: Boros, E E.]] | ||
[[Category: Deaton, D | [[Category: Deaton, D N.]] | ||
[[Category: Hassell, A | [[Category: Hassell, A M.]] | ||
[[Category: Jr., D | [[Category: Jr., D H.Willard.]] | ||
[[Category: McFadyen, R | [[Category: McFadyen, R B.]] | ||
[[Category: Miller, A | [[Category: Miller, A B.]] | ||
[[Category: Miller, L | [[Category: Miller, L R.]] | ||
[[Category: Shewchuk, L | [[Category: Shewchuk, L M.]] | ||
[[Category: Thompson, J | [[Category: Thompson, J B.]] | ||
[[Category: Wright, L | [[Category: Wright, L L.]] | ||
[[Category: MYE]] | [[Category: MYE]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: catk]] | [[Category: catk]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:03:22 2008'' | ||
