8rxr: Difference between revisions

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'''Unreleased structure'''


The entry 8rxr is ON HOLD  until Paper Publication
==Crystal structure of VPS34 in complex with inhibitor SB02024==
 
<StructureSection load='8rxr' size='340' side='right'caption='[[8rxr]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
Authors: Tresaugues, L., Yu, Y., Bogdan, M., Parpal, S., Silvander, C., Lindstrom, J., Simeon, J., Timson, M.J., Al-Hashimi, H., Smith, B.D., Flynn, D.L., Viklund, J., Martinsson, J., De Milito, A., Andersson, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8rxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RXR FirstGlance]. <br>
Description: Crystal structure of VPS34 in complex with inhibitor SB02024
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H4E:4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one'>A1H4E</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Flynn, D.L]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rxr OCA], [https://pdbe.org/8rxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rxr RCSB], [https://www.ebi.ac.uk/pdbsum/8rxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rxr ProSAT]</span></td></tr>
[[Category: Lindstrom, J]]
</table>
[[Category: Timson, M.J]]
== Function ==
[[Category: Parpal, S]]
[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
[[Category: Tresaugues, L]]
== References ==
[[Category: Yu, Y]]
<references/>
[[Category: De Milito, A]]
__TOC__
[[Category: Martinsson, J]]
</StructureSection>
[[Category: Smith, B.D]]
[[Category: Homo sapiens]]
[[Category: Bogdan, M]]
[[Category: Large Structures]]
[[Category: Andersson, M]]
[[Category: Al-Hashimi H]]
[[Category: Silvander, C]]
[[Category: Andersson M]]
[[Category: Simeon, J]]
[[Category: Bogdan M]]
[[Category: Viklund, J]]
[[Category: De Milito A]]
[[Category: Al-Hashimi, H]]
[[Category: Flynn DL]]
[[Category: Lindstrom J]]
[[Category: Martinsson J]]
[[Category: Parpal S]]
[[Category: Silvander C]]
[[Category: Simeon J]]
[[Category: Smith BD]]
[[Category: Timson MJ]]
[[Category: Tresaugues L]]
[[Category: Viklund J]]
[[Category: Yu Y]]
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