1qkl: Difference between revisions

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[[Image:1qkl.jpg|left|200px]]
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[[Image:1qkl.png|left|200px]]


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{{STRUCTURE_1qkl|  PDB=1qkl  |  SCENE=  }}  
{{STRUCTURE_1qkl|  PDB=1qkl  |  SCENE=  }}  


'''HRPABC14.4, ESSENTIAL SUBUNIT OF HUMAN RNA POLYMERASES I, II AND III'''
===HRPABC14.4, ESSENTIAL SUBUNIT OF HUMAN RNA POLYMERASES I, II AND III===




==Overview==
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The protein hRPABC14.4 is an essential subunit of human RNA polymerases I, II, and III and is required for the transcription of all human nuclear genes. The structure of hRPABC14.4 was determined by nuclear magnetic resonance spectroscopy. The protein fold comprises a highly conserved central domain forming two antiparallel alpha-helices flanked by the less conserved N- and C-terminal regions forming a five-stranded beta-sandwich. Amino acids from the two helices participate in the generation of a hydrophobic surface area which is conserved in all eukaryotic and archaeal homologous subunits, and likely constitutes a critical macromolecular interaction interface. The hRPABC14.4 structure accounts for mutagenesis results in Saccharomyces cerevisiae and provides a structural working model for elucidating the role of this subunit in the molecular architecture and function of the human nuclear RNA polymerases.
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{{ABSTRACT_PUBMED_10542096}}


==About this Structure==
==About this Structure==
1QKL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKL OCA].  
1QKL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKL OCA].  


==Reference==
==Reference==
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[[Category: Rna polymerase]]
[[Category: Rna polymerase]]
[[Category: Transcription]]
[[Category: Transcription]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:23:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:19:12 2008''

Revision as of 13:19, 27 July 2008

File:1qkl.png

Template:STRUCTURE 1qkl

HRPABC14.4, ESSENTIAL SUBUNIT OF HUMAN RNA POLYMERASES I, II AND III

Template:ABSTRACT PUBMED 10542096

About this Structure

1QKL is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the hRPABC14.4 subunit of human RNA polymerases., del Rio-Portilla F, Gaskell A, Gilbert D, Ladias JA, Wagner G, Nat Struct Biol. 1999 Nov;6(11):1039-42. PMID:10542096

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