1qlb: Difference between revisions

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[[Image:1qlb.jpg|left|200px]]
{{Seed}}
[[Image:1qlb.png|left|200px]]


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{{STRUCTURE_1qlb|  PDB=1qlb  |  SCENE=  }}  
{{STRUCTURE_1qlb|  PDB=1qlb  |  SCENE=  }}  


'''RESPIRATORY COMPLEX II-LIKE FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES'''
===RESPIRATORY COMPLEX II-LIKE FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES===




==Overview==
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Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalysed by the related complex II of the respiratory chain (succinate dehydrogenase). Here we describe the crystal structure at 2.2 A resolution of the three protein subunits containing fumarate reductase from the anaerobic bacterium Wolinella succinogenes. Subunit A contains the site of fumarate reduction and a covalently bound flavin adenine dinucleotide prosthetic group. Subunit B contains three iron-sulphur centres. The menaquinol-oxidizing subunit C consists of five membrane-spanning, primarily helical segments and binds two haem b molecules. On the basis of the structure, we propose a pathway of electron transfer from the dihaem cytochrome b to the site of fumarate reduction and a mechanism of fumarate reduction. The relative orientations of the soluble and membrane-embedded subunits of succinate:quinone oxidoreductases appear to be unique.
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{{ABSTRACT_PUBMED_10586875}}


==About this Structure==
==About this Structure==
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[[Category: Respiratory chain]]
[[Category: Respiratory chain]]
[[Category: Succinate dehydrogenase]]
[[Category: Succinate dehydrogenase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:24:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:03:54 2008''

Revision as of 12:03, 29 July 2008

File:1qlb.png

Template:STRUCTURE 1qlb

RESPIRATORY COMPLEX II-LIKE FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES

Template:ABSTRACT PUBMED 10586875

About this Structure

1QLB is a Protein complex structure of sequences from Wolinella succinogenes. Full crystallographic information is available from OCA.

Reference

Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution., Lancaster CR, Kroger A, Auer M, Michel H, Nature. 1999 Nov 25;402(6760):377-85. PMID:10586875

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