1qmw: Difference between revisions

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[[Image:1qmw.jpg|left|200px]]
{{Seed}}
[[Image:1qmw.png|left|200px]]


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{{STRUCTURE_1qmw|  PDB=1qmw  |  SCENE=  }}  
{{STRUCTURE_1qmw|  PDB=1qmw  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI'''
===SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI===




==Overview==
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The nuclear magnetic resonance solution structure of alpha-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that alpha-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are made between the SI solution structure and the solution and crystal structures of alpha-conotoxin GI. Surprisingly, a high degree of similarity between the backbone conformations of the GI crystal and the SI solution structures is seen in the region of lowest sequence homology, namely residues Gly-8 to Ser-12. This similarity is more surprising when considering that in SI a proline replaces the Arg-9 found in GI. The correspondence in conformation in this region provides the definitive evidence that it is the loss of the arginine basic charge at residue 9 which determines the differences in toxicity between GI and SI, rather than any changes in conformation induced by the cyclic proline residue.
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{{ABSTRACT_PUBMED_10913630}}


==About this Structure==
==About this Structure==
1QMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA].  
1QMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA].  


==Reference==
==Reference==
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[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Venom]]
[[Category: Venom]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:27:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:25:54 2008''

Revision as of 09:26, 27 July 2008

File:1qmw.png

Template:STRUCTURE 1qmw

SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI

Template:ABSTRACT PUBMED 10913630

About this Structure

1QMW is a Single protein structure of sequence from Conus striatus. Full experimental information is available from OCA.

Reference

Solution structure of alpha-conotoxin SI., Benie AJ, Whitford D, Hargittai B, Barany G, Janes RW, FEBS Lett. 2000 Jul 7;476(3):287-95. PMID:10913630

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