1qnd: Difference between revisions

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[[Image:1qnd.gif|left|200px]]
{{Seed}}
[[Image:1qnd.png|left|200px]]


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{{STRUCTURE_1qnd|  PDB=1qnd  |  SCENE=  }}  
{{STRUCTURE_1qnd|  PDB=1qnd  |  SCENE=  }}  


'''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES'''
===STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES===




==Overview==
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The determination of the NMR structure of the sterol carrier protein-2 (SCP2), analysis of backbone (15)N spin relaxation parameters and NMR studies of nitroxide spin-labeled substrate binding are presented as a new basis for investigations of the mode of action of SCP2. The SCP2 fold is formed by a five-stranded beta-sheet and four alpha-helices. Fatty acid binding to a hydrophobic surface area formed by amino acid residues of the first and third helices, and the beta-sheet, which are all located in the polypeptide segment 8-102, was identified with the use of the spin-labeled substrate 16-doxylstearic acid. In the free protein, the lipid-binding site is covered by the C-terminal segment 105-123, suggesting that this polypeptide segment, which carries the peroxisomal targeting signal (PTS1), might be involved in the regulation of ligand binding.
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{{ABSTRACT_PUBMED_10623549}}


==About this Structure==
==About this Structure==
1QND is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QND OCA].  
1QND is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QND OCA].  


==Reference==
==Reference==
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[[Category: Protein structure]]
[[Category: Protein structure]]
[[Category: Sterol carrier protein 2]]
[[Category: Sterol carrier protein 2]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:28:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:00:44 2008''

Revision as of 00:00, 29 July 2008

File:1qnd.png

Template:STRUCTURE 1qnd

STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 10623549

About this Structure

1QND is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure of the sterol carrier protein-2: implications for the biological role., Garcia FL, Szyperski T, Dyer JH, Choinowski T, Seedorf U, Hauser H, Wuthrich K, J Mol Biol. 2000 Jan 21;295(3):595-603. PMID:10623549

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