1qqp: Difference between revisions

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[[Image:1qqp.gif|left|200px]]
{{Seed}}
[[Image:1qqp.png|left|200px]]


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{{STRUCTURE_1qqp|  PDB=1qqp  |  SCENE=  }}  
{{STRUCTURE_1qqp|  PDB=1qqp  |  SCENE=  }}  


'''FOOT-AND-MOUTH DISEASE VIRUS/ OLIGOSACCHARIDE RECEPTOR COMPLEX.'''
===FOOT-AND-MOUTH DISEASE VIRUS/ OLIGOSACCHARIDE RECEPTOR COMPLEX.===




==Overview==
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Heparan sulfate has an important role in cell entry by foot-and-mouth disease virus (FMDV). We find that subtype O1 FMDV binds this glycosaminoglycan with a high affinity by immobilizing a specific highly abundant motif of sulfated sugars. The binding site is a shallow depression on the virion surface, located at the junction of the three major capsid proteins, VP1, VP2 and VP3. Two pre-formed sulfate-binding sites control receptor specificity. Residue 56 of VP3, an arginine in this virus, is critical to this recognition, forming a key component of both sites. This residue is a histidine in field isolates of the virus, switching to an arginine in adaptation to tissue culture, forming the high affinity heparan sulfate-binding site. We postulate that this site is a conserved feature of FMDVs, such that in the infected animal there is a biological advantage to low affinity, or more selective, interactions with glycosaminoglycan receptors.
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{{ABSTRACT_PUBMED_9927414}}


==About this Structure==
==About this Structure==
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[[Category: Virus-receptor interactions/protein-carbohydrate interaction]]
[[Category: Virus-receptor interactions/protein-carbohydrate interaction]]
[[Category: Virus/viral protein]]
[[Category: Virus/viral protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:35:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:12:49 2008''

Revision as of 05:12, 29 July 2008

File:1qqp.png

Template:STRUCTURE 1qqp

FOOT-AND-MOUTH DISEASE VIRUS/ OLIGOSACCHARIDE RECEPTOR COMPLEX.

Template:ABSTRACT PUBMED 9927414

About this Structure

1QQP is a Single protein structure of sequence from Foot-and-mouth disease virus. This structure supersedes the now removed PDB entry 1fhp. Full crystallographic information is available from OCA.

Reference

The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex., Fry EE, Lea SM, Jackson T, Newman JW, Ellard FM, Blakemore WE, Abu-Ghazaleh R, Samuel A, King AM, Stuart DI, EMBO J. 1999 Feb 1;18(3):543-54. PMID:9927414

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