1t2u: Difference between revisions
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New page: left|200px<br /> <applet load="1t2u" size="450" color="white" frame="true" align="right" spinBox="true" caption="1t2u, resolution 2.80Å" /> '''Structural basis of... |
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[[Image:1t2u.gif|left|200px]]<br /> | [[Image:1t2u.gif|left|200px]]<br /><applet load="1t2u" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1t2u" size=" | |||
caption="1t2u, resolution 2.80Å" /> | caption="1t2u, resolution 2.80Å" /> | ||
'''Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1: structure of BRCA1 missense variant V1809F'''<br /> | '''Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1: structure of BRCA1 missense variant V1809F'''<br /> | ||
==Overview== | ==Overview== | ||
The BRCT repeats in BRCA1 are essential for its tumor suppressor activity | The BRCT repeats in BRCA1 are essential for its tumor suppressor activity and interact with phosphorylated protein targets containing the sequence pSer-X-X-Phe, where X indicates any residue. The structure of the tandem BRCA1 BRCT repeats bound to an optimized phosphopeptide reveals that the N-terminal repeat harbors a conserved BRCT phosphoserine-binding pocket, while the interface between the repeats forms a hydrophobic groove that recognizes the phenylalanine. Crystallographic and biochemical data suggest that the structural integrity of both binding sites is essential for peptide recognition. The diminished peptide-binding capacity observed for cancer-associated BRCA1-BRCT variants may explain the enhanced cancer risks associated with these mutations. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1T2U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CO and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1T2U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CO:'>CO</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2U OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Duong, D | [[Category: Duong, D D.]] | ||
[[Category: Glover, J | [[Category: Glover, J N.M.]] | ||
[[Category: Lee, M | [[Category: Lee, M S.]] | ||
[[Category: Williams, R | [[Category: Williams, R S.]] | ||
[[Category: CO]] | [[Category: CO]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: phospho-peptide]] | [[Category: phospho-peptide]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:09:19 2008'' | ||
