1t2v: Difference between revisions
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New page: left|200px<br /> <applet load="1t2v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1t2v, resolution 3.30Å" /> '''Structural basis of... |
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[[Image:1t2v.gif|left|200px]]<br /> | [[Image:1t2v.gif|left|200px]]<br /><applet load="1t2v" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1t2v" size=" | |||
caption="1t2v, resolution 3.30Å" /> | caption="1t2v, resolution 3.30Å" /> | ||
'''Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide'''<br /> | '''Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide'''<br /> | ||
==Overview== | ==Overview== | ||
The BRCT repeats in BRCA1 are essential for its tumor suppressor activity | The BRCT repeats in BRCA1 are essential for its tumor suppressor activity and interact with phosphorylated protein targets containing the sequence pSer-X-X-Phe, where X indicates any residue. The structure of the tandem BRCA1 BRCT repeats bound to an optimized phosphopeptide reveals that the N-terminal repeat harbors a conserved BRCT phosphoserine-binding pocket, while the interface between the repeats forms a hydrophobic groove that recognizes the phenylalanine. Crystallographic and biochemical data suggest that the structural integrity of both binding sites is essential for peptide recognition. The diminished peptide-binding capacity observed for cancer-associated BRCA1-BRCT variants may explain the enhanced cancer risks associated with these mutations. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1T2V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1T2V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2V OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Glover, J | [[Category: Glover, J N.M.]] | ||
[[Category: Hau, D | [[Category: Hau, D D.]] | ||
[[Category: Lee, M | [[Category: Lee, M S.]] | ||
[[Category: Williams, R | [[Category: Williams, R S.]] | ||
[[Category: brca1]] | [[Category: brca1]] | ||
[[Category: brct]] | [[Category: brct]] | ||
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[[Category: phosphopeptide]] | [[Category: phosphopeptide]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:09:17 2008'' | ||
