1quw: Difference between revisions

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[[Image:1quw.jpg|left|200px]]
{{Seed}}
[[Image:1quw.png|left|200px]]


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{{STRUCTURE_1quw|  PDB=1quw  |  SCENE=  }}  
{{STRUCTURE_1quw|  PDB=1quw  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE THIOREDOXIN FROM BACILLUS ACIDOCALDARIUS'''
===SOLUTION STRUCTURE OF THE THIOREDOXIN FROM BACILLUS ACIDOCALDARIUS===




==Overview==
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The thioredoxin (Trx) from Bacillus acidocaldarius (BacTrx), an eubacterium growing optimally at 333 K, is the first Trx described to date from a moderate thermophilic source. To understand the molecular basis of its thermostability, the three-dimensional structure in the oxidized form was determined by NMR methods. A total of 2276 1H-NMR derived distance constraints along with 23 hydrogen-bonds, 72 phi and 27 chi1 torsion angle restraints, were used in a protocol employing simulated annealing followed by restrained molecular dynamics and restrained energy minimization. BacTrx consists of a well-defined core region of five strands of beta-sheet, surrounded by four exposed alpha-helices, features shared by other members of the thioredoxin family. The BacTrx 3D structure was compared with the Escherichia coli Trx (EcTrx) determined by X-ray crystallographic diffraction, and a number of structural differences were observed that may contribute to its thermostabilty. The results of structural analysis indicated that protein stability is due to cumulative effects, the main factor being an increased number of ionic interactions cross-linking different secondary structural elements and clamping the C-terminal alpha-helix to the core of the protein.
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{{ABSTRACT_PUBMED_10632710}}


==About this Structure==
==About this Structure==
1QUW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QUW OCA].  
1QUW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QUW OCA].  


==Reference==
==Reference==
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[[Category: Alpha/beta open-twisted protein]]
[[Category: Alpha/beta open-twisted protein]]
[[Category: Thiol-disulfide]]
[[Category: Thiol-disulfide]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:44:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:44:40 2008''

Revision as of 15:44, 27 July 2008

File:1quw.png

Template:STRUCTURE 1quw

SOLUTION STRUCTURE OF THE THIOREDOXIN FROM BACILLUS ACIDOCALDARIUS

Template:ABSTRACT PUBMED 10632710

About this Structure

1QUW is a Single protein structure of sequence from Alicyclobacillus acidocaldarius. Full experimental information is available from OCA.

Reference

NMR solution structure of a novel thioredoxin from Bacillus acidocaldarius possible determinants of protein stability., Nicastro G, De Chiara C, Pedone E, Tato M, Rossi M, Bartolucci S, Eur J Biochem. 2000 Jan;267(2):403-13. PMID:10632710

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