1qwf: Difference between revisions

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[[Image:1qwf.jpg|left|200px]]
{{Seed}}
[[Image:1qwf.png|left|200px]]


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{{STRUCTURE_1qwf|  PDB=1qwf  |  SCENE=  }}  
{{STRUCTURE_1qwf|  PDB=1qwf  |  SCENE=  }}  


'''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12'''
===C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12===




==Overview==
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Two dodecapeptides belonging to distinct classes of Src homology 3 (SH3) ligands and selected from biased phage display libraries were used to investigate interactions between a specificity pocket in the Src SH3 domain and ligant residues flanking the proline-rich core. The solution structures of c-Src SH3 complexed with these peptides were solved by NMR. In addition to proline-rich, polyproline type II helix-forming core, the class I and II ligands each possesses a flanking sequence that occupies a large pocket between the RT and n-Src loops of the SH3 domain. Structural and mutational analyses illustrate how the two classes of SH3 ligands exploit a specificity pocket on the receptor differently to increase binding affinity and specificity.
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{{ABSTRACT_PUBMED_8618911}}


==About this Structure==
==About this Structure==
1QWF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWF OCA].  
1QWF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWF OCA].  


==Reference==
==Reference==
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[[Category: Class i ligand complex]]
[[Category: Class i ligand complex]]
[[Category: Src sh3 domain]]
[[Category: Src sh3 domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:46:39 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:54:51 2008''

Revision as of 01:54, 29 July 2008

File:1qwf.png

Template:STRUCTURE 1qwf

C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12

Template:ABSTRACT PUBMED 8618911

About this Structure

1QWF is a Single protein structure of sequence from Avian sarcoma virus. Full experimental information is available from OCA.

Reference

Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:8618911

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