1qwp: Difference between revisions

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[[Image:1qwp.gif|left|200px]]
{{Seed}}
[[Image:1qwp.png|left|200px]]


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{{STRUCTURE_1qwp|  PDB=1qwp  |  SCENE=  }}  
{{STRUCTURE_1qwp|  PDB=1qwp  |  SCENE=  }}  


'''NMR analysis of 25-35 fragment of beta amyloid peptide'''
===NMR analysis of 25-35 fragment of beta amyloid peptide===




==Overview==
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The design of molecules able to interact with the amyloid peptides either as inhibitors of fibril formation or as inhibitors of amyloid membrane pore formation represents one of the most relevant approaches in the development of anti-Alzheimer therapies. Abeta-(25-35), sequence GSNKGAIIGLM, is a highly toxic synthetic derivative of amyloid beta-peptides (Abeta-peptides), which forms fibrillary aggregates. Here, we report the NMR and CD investigation of Abeta-(25-35) in a membrane-mimicking environment and in isotropic mixtures of water and fluoro-alcohols to scan its conformational properties as a function of the medium. The analysis of the 3D structures in the mentioned conditions indicates a propensity of the peptide to behave as a typical transmembrane helix in the lipidic environment. In media characterized by different polarity, it loses the structural regularity at specific points of the sequence as a function of the environment. Furthermore, a comparison with the solution structure of full-length amyloid peptides suggests a role for the 25-27 kink region, which appears to be a general feature of all peptides under the solution conditions explored.
The line below this paragraph, {{ABSTRACT_PUBMED_15293994}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15293994 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15293994}}


==About this Structure==
==About this Structure==
1QWP is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWP OCA].  
1QWP is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWP OCA].  


==Reference==
==Reference==
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[[Category: Ursi, A M.D.]]
[[Category: Ursi, A M.D.]]
[[Category: Amyloid beta peptide- kink structure]]
[[Category: Amyloid beta peptide- kink structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:47:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:52:18 2008''

Revision as of 23:52, 28 July 2008

File:1qwp.png

Template:STRUCTURE 1qwp

NMR analysis of 25-35 fragment of beta amyloid peptide

Template:ABSTRACT PUBMED 15293994

About this Structure

1QWP is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of amyloid beta-peptide (25-35) in different media., D'Ursi AM, Armenante MR, Guerrini R, Salvadori S, Sorrentino G, Picone D, J Med Chem. 2004 Aug 12;47(17):4231-8. PMID:15293994

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