1qyt: Difference between revisions

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[[Image:1qyt.jpg|left|200px]]
{{Seed}}
[[Image:1qyt.png|left|200px]]


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{{STRUCTURE_1qyt|  PDB=1qyt  |  SCENE=  }}  
{{STRUCTURE_1qyt|  PDB=1qyt  |  SCENE=  }}  


'''Solution structure of fragment (25-35) of beta amyloid peptide in SDS micellar solution'''
===Solution structure of fragment (25-35) of beta amyloid peptide in SDS micellar solution===




==Overview==
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The design of molecules able to interact with the amyloid peptides either as inhibitors of fibril formation or as inhibitors of amyloid membrane pore formation represents one of the most relevant approaches in the development of anti-Alzheimer therapies. Abeta-(25-35), sequence GSNKGAIIGLM, is a highly toxic synthetic derivative of amyloid beta-peptides (Abeta-peptides), which forms fibrillary aggregates. Here, we report the NMR and CD investigation of Abeta-(25-35) in a membrane-mimicking environment and in isotropic mixtures of water and fluoro-alcohols to scan its conformational properties as a function of the medium. The analysis of the 3D structures in the mentioned conditions indicates a propensity of the peptide to behave as a typical transmembrane helix in the lipidic environment. In media characterized by different polarity, it loses the structural regularity at specific points of the sequence as a function of the environment. Furthermore, a comparison with the solution structure of full-length amyloid peptides suggests a role for the 25-27 kink region, which appears to be a general feature of all peptides under the solution conditions explored.
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{{ABSTRACT_PUBMED_15293994}}


==About this Structure==
==About this Structure==
1QYT is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYT OCA].  
1QYT is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYT OCA].  


==Reference==
==Reference==
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[[Category: Ursi, A M.D.]]
[[Category: Ursi, A M.D.]]
[[Category: Amyloid beta peptide- kink structure]]
[[Category: Amyloid beta peptide- kink structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:52:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:50:08 2008''

Revision as of 05:50, 28 July 2008

File:1qyt.png

Template:STRUCTURE 1qyt

Solution structure of fragment (25-35) of beta amyloid peptide in SDS micellar solution

Template:ABSTRACT PUBMED 15293994

About this Structure

1QYT is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of amyloid beta-peptide (25-35) in different media., D'Ursi AM, Armenante MR, Guerrini R, Salvadori S, Sorrentino G, Picone D, J Med Chem. 2004 Aug 12;47(17):4231-8. PMID:15293994

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