1qz2: Difference between revisions

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[[Image:1qz2.~~jpg~~|left|200px]]

[[Image:1qz2.png|left|200px]]

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~~'''~~Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90~~'''~~

===Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90===

~~==Overview==~~

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~~FK506-binding protein 52 (FKBP52)~~, ~~which binds FK506 and possesses peptidylprolyl isomerase activity~~, ~~is an important immunophilin involved in~~ the ~~heterocomplex of steroid receptors with heat-shock protein 90. Here we report~~ the ~~crystal structures of two overlapped fragments [N~~(~~1-260) and C(145-459)] of FKBP52 and the complex with a C-terminal pentapeptide from heat-shock protein 90. Based~~ on ~~the structures of these two overlapped fragments, the complete putative structure of FKBP52 can be defined~~. ~~The structure of FKBP52 is composed of two consecutive FKBP domains, a tetratricopeptide repeat domain and a short helical domain beyond the final tetratricopeptide repeat motif~~. ~~Key structural differences between FKBP52 and FKBP51~~, ~~including the relative orientations of the four domains and some important residue substitutions, could account for~~ the ~~differential functions of FKBPs~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15159550}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15159550 is the PubMed ID number.

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==About this Structure==

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[[Category: Isomerase]]

[[Category: Rotamase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:52:39 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:46:59 2008''

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-[[Image:1qz2.jpg|left|200px]]
+{{Seed}}
+[[Image:1qz2.png|left|200px]]
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 {{STRUCTURE_1qz2|  PDB=1qz2  |  SCENE=  }}
-'''Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90'''
+===Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90===
-==Overview==
+<!--
-FK506-binding protein 52 (FKBP52), which binds FK506 and possesses peptidylprolyl isomerase activity, is an important immunophilin involved in the heterocomplex of steroid receptors with heat-shock protein 90. Here we report the crystal structures of two overlapped fragments [N(1-260) and C(145-459)] of FKBP52 and the complex with a C-terminal pentapeptide from heat-shock protein 90. Based on the structures of these two overlapped fragments, the complete putative structure of FKBP52 can be defined. The structure of FKBP52 is composed of two consecutive FKBP domains, a tetratricopeptide repeat domain and a short helical domain beyond the final tetratricopeptide repeat motif. Key structural differences between FKBP52 and FKBP51, including the relative orientations of the four domains and some important residue substitutions, could account for the differential functions of FKBPs.
+The line below this paragraph, {{ABSTRACT_PUBMED_15159550}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15159550 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15159550}}
 ==About this Structure==
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 [[Category: Isomerase]]
 [[Category: Rotamase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:52:39 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:46:59 2008''