1qz7: Difference between revisions

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[[Image:1qz7.gif|left|200px]]
{{Seed}}
[[Image:1qz7.png|left|200px]]


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{{STRUCTURE_1qz7|  PDB=1qz7  |  SCENE=  }}  
{{STRUCTURE_1qz7|  PDB=1qz7  |  SCENE=  }}  


'''Beta-catenin binding domain of Axin in complex with beta-catenin'''
===Beta-catenin binding domain of Axin in complex with beta-catenin===




==Overview==
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The "beta-catenin destruction complex" is central to canonical Wnt/beta-catenin signaling. The scaffolding protein Axin and the tumor suppressor adenomatous polyposis coli protein (APC) are critical components of this complex, required for rapid beta-catenin turnover. We determined the crystal structure of a complex between beta-catenin and the beta-catenin-binding domain of Axin (Axin-CBD). The Axin-CBD forms a helix that occupies the groove formed by the third and fourth armadillo repeats of beta-catenin and thus precludes the simultaneous binding of other beta-catenin partners in this region. Our biochemical studies demonstrate that, when phosphorylated, the 20-amino acid repeat region of APC competes with Axin for binding to beta-catenin. We propose that a key function of APC in the beta-catenin destruction complex is to remove phosphorylated beta-catenin product from the active site.
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{{ABSTRACT_PUBMED_14600025}}


==Disease==
==Disease==
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[[Category: Beta-catenin]]
[[Category: Beta-catenin]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:53:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:45:49 2008''

Revision as of 15:45, 28 July 2008

File:1qz7.png

Template:STRUCTURE 1qz7

Beta-catenin binding domain of Axin in complex with beta-catenin

Template:ABSTRACT PUBMED 14600025

Disease

Known disease associated with this structure: Colorectal cancer OMIM:[116806], Hepatoblastoma OMIM:[116806], Hepatocellular carcinoma OMIM:[116806], Ovarian carcinoma, endometrioid type OMIM:[116806], Pilomatricoma OMIM:[116806]

About this Structure

1QZ7 is a Protein complex structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex., Xing Y, Clements WK, Kimelman D, Xu W, Genes Dev. 2003 Nov 15;17(22):2753-64. Epub 2003 Nov 4. PMID:14600025

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