1qze: Difference between revisions

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[[Image:1qze.gif|left|200px]]
{{Seed}}
[[Image:1qze.png|left|200px]]


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{{STRUCTURE_1qze|  PDB=1qze  |  SCENE=  }}  
{{STRUCTURE_1qze|  PDB=1qze  |  SCENE=  }}  


'''HHR23a protein structure based on residual dipolar coupling data'''
===HHR23a protein structure based on residual dipolar coupling data===




==Overview==
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The Rad23 family of proteins, including the human homologs hHR23a and hHR23b, stimulates nucleotide excision repair and has been shown to provide a novel link between proteasome-mediated protein degradation and DNA repair. In this work, we illustrate how the proteasomal subunit S5a regulates hHR23a protein structure. By using NMR spectroscopy, we have elucidated the structure and dynamic properties of the 40-kDa hHR23a protein and show it to contain four structured domains connected by flexible linker regions. In addition, we reveal that these domains interact in an intramolecular fashion, and by using residual dipolar coupling data in combination with chemical shift perturbation analysis, we present the hHR23a structure. By itself, hHR23a adopts a closed conformation defined by the interaction of an N-terminal ubiquitin-like domain with two ubiquitin-associated domains. Interestingly, binding of the proteasomal subunit S5a disrupts the hHR23a interdomain interactions and thereby causes it to adopt an opened conformation.
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{{ABSTRACT_PUBMED_14557549}}


==About this Structure==
==About this Structure==
1QZE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZE OCA].  
1QZE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZE OCA].  


==Reference==
==Reference==
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[[Category: Proteasome-mediated degradation]]
[[Category: Proteasome-mediated degradation]]
[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:53:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:44:06 2008''
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