4g6a: Difference between revisions
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<StructureSection load='4g6a' size='340' side='right'caption='[[4g6a]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4g6a' size='340' side='right'caption='[[4g6a]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_hominis Hepacivirus hominis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G6A FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.501Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.501Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [https://pdbe.org/4g6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [https://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [https://pdbe.org/4g6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [https://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr> | ||
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/Q9YK84_9HEPC Q9YK84_9HEPC] | [https://www.uniprot.org/uniprot/Q9YK84_9HEPC Q9YK84_9HEPC] | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We have determined the crystal structure of broadly neutralizing antibody (bnAb) AP33 bound to a peptide corresponding to hepatitis C virus (HCV) E2 envelope glycoprotein antigenic site 412-423. Comparison with bnAb HCV1 bound to the same epitope reveals a different angle of approach to the antigen by bnAb AP33, and slight variation in its beta-hairpin conformation of the epitope. These structures establish two different modes of binding to E2 that antibodies adopt to neutralize diverse HCV. | |||
Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412-423 in complex with antibody AP33.,Kong L, Giang E, Nieusma T, Robbins JB, Deller MC, Stanfield RL, Wilson IA, Law M J Virol. 2012 Sep 12. PMID:22973046<ref>PMID:22973046</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4g6a" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Hepacivirus | [[Category: Hepacivirus hominis]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
Latest revision as of 10:01, 30 October 2024
Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33
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