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| {{STRUCTURE_1r5m| PDB=1r5m | SCENE= }} | | {{STRUCTURE_1r5m| PDB=1r5m | SCENE= }} |
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| '''Crystal Structure Of The C-Terminal WD40 Domain Of Sif2'''
| | ===Crystal Structure Of The C-Terminal WD40 Domain Of Sif2=== |
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| ==Overview==
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| In Saccharomyces cerevisiae, the SIF2 gene product is an integral component of the Set3 complex (SET3C), an assembly of proteins with some homology to the human SMRT and N-CoR corepressor complexes. SET3C has histone deacetylase activity that is responsible for repressing a set of meiotic genes. We have determined the X-ray crystal structure of a 46 kDa C-terminal domain of a SET3C core protein, Sif2p to 1.55 A resolution and a crystallographic R-factor of 19.0%. This domain contains an unusual eight-bladed beta-propeller structure, which differs from other transcriptional corepressor structures such as yeast Tup1p and human groucho (Gro)/TLE1, which have only seven. We have demonstrated intact Sif2p is a tetramer and the N-terminal LisH (Lis-homology)-containing domain mediates tetramerization and interaction with another component of SET3C, Snt1p. Multiple sequence alignments indicate that a surface on the "top" of the protein is conserved among species, suggesting that it may play a common role in binding partner proteins. Since Sif2p appears to be the yeast homolog of human TBL1 and TBLR1, which function in the N-CoR/SMRT complexes, its structural and oligomeric properties are likely to be very similar.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16051270}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16051270 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16051270}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Transcription corepressor]] | | [[Category: Transcription corepressor]] |
| [[Category: Wd40 repeat]] | | [[Category: Wd40 repeat]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:06:40 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:01:26 2008'' |
