1r6g: Difference between revisions

Line 1:

[[Image:1r6g.~~gif~~|left|200px]]

[[Image:1r6g.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound~~'''~~

===Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound===

~~==Overview==~~

<!--

~~A set of thyromimetics having improved selectivity for TR~~-~~beta1 were prepared by replacing the 3'~~-~~isopropyl group of 2 and 3 with substituents having increased steric bulk. From~~ this ~~limited SAR study~~, the ~~most potent and selective compounds identified were derived from 2 and contained a 3'-phenyl moiety bearing small hydrophobic groups meta~~ to the ~~biphenyl link~~. ~~X-ray crystal data of 15c complexed with TR-beta1 LBD shows methionine 442 to be displaced by~~ the ~~bulky R3' phenyl ethyl amide side chain~~. ~~Movement of this amino acid side chain provides an expanded pocket for the bulky side chain while the ligand~~-~~receptor complex retains full agonist activity.~~

The line below this paragraph, {{ABSTRACT_PUBMED_15177471}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15177471 is the PubMed ID number.

-->

==About this Structure==

Line 40:

Line 44:

[[Category: Sheppard, C.]]

[[Category: Alpha helical]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 07~~:08:36 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:41:57 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1r6g.gif|left|200px]]
+{{Seed}}
+[[Image:1r6g.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1r6g|  PDB=1r6g  |  SCENE=  }}
-'''Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound'''
+===Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound===
-==Overview==
+<!--
-A set of thyromimetics having improved selectivity for TR-beta1 were prepared by replacing the 3'-isopropyl group of 2 and 3 with substituents having increased steric bulk. From this limited SAR study, the most potent and selective compounds identified were derived from 2 and contained a 3'-phenyl moiety bearing small hydrophobic groups meta to the biphenyl link. X-ray crystal data of 15c complexed with TR-beta1 LBD shows methionine 442 to be displaced by the bulky R3' phenyl ethyl amide side chain. Movement of this amino acid side chain provides an expanded pocket for the bulky side chain while the ligand-receptor complex retains full agonist activity.
+The line below this paragraph, {{ABSTRACT_PUBMED_15177471}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15177471 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15177471}}
 ==About this Structure==
@@ Line 40: / Line 44: @@
 [[Category: Sheppard, C.]]
 [[Category: Alpha helical]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:08:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:41:57 2008''