1tou: Difference between revisions

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[[Image:1tou.gif|left|200px]]<br />

[[Image:1tou.gif|left|200px]]<br /><applet load="1tou" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1tou" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1tou, resolution 2.00Å" />

'''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand'''<br />

==Overview==

The synthesis and biological evaluation of novel human A-FABP inhibitors, based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is, described. Two series of compounds, bearing either an amino or carbon, substituent in the 2-position of the pyrimidine ring were investigated., Modification of substituents and chain length optimization led to novel, compounds with low micromolar activity and good selectivity for human, A-FABP.

The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.

==About this Structure==

1TOU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with B1V as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1TOU OCA].

1TOU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=B1V:'>B1V</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOU OCA].

==Reference==

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[[Category: transport]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 19~~:26:~~27 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:15:48 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1tou.gif|left|200px]]<br />
+[[Image:1tou.gif|left|200px]]<br /><applet load="1tou" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1tou" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1tou, resolution 2.00&Aring;" />
 '''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand'''<br />
 ==Overview==
-The synthesis and biological evaluation of novel human A-FABP inhibitors, based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is, described. Two series of compounds, bearing either an amino or carbon, substituent in the 2-position of the pyrimidine ring were investigated., Modification of substituents and chain length optimization led to novel, compounds with low micromolar activity and good selectivity for human, A-FABP.
+The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.
 ==About this Structure==
-TOU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with B1V as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TOU OCA].
+TOU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=B1V:'>B1V</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOU OCA].
 ==Reference==
@@ Line 24: / Line 23: @@
 [[Category: transport]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:26:27 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:15:48 2008''