1tow: Difference between revisions

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[[Image:1tow.gif|left|200px]]<br />

[[Image:1tow.gif|left|200px]]<br /><applet load="1tow" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1tow" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1tow, resolution 2.00Å" />

'''Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand'''<br />

==Overview==

Low micromolar human A-FABP inhibitors were found by utilizing a, fluorescence polarization assay, X-ray crystallography and modeling. The, carbazole- and indole-based inhibitors displayed approximately 10-fold, preferences over human H-FABP and E-FABP, and are highly selective against, I-FABP. This communication describes the SAR for drug-like synthetic, inhibitors of human A-FABP.

Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.

==About this Structure==

1TOW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CRZ as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1TOW OCA].

1TOW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CRZ:'>CRZ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOW OCA].

==Reference==

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[[Category: transport]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 19~~:26:~~30 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:15:54 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1tow.gif|left|200px]]<br />
+[[Image:1tow.gif|left|200px]]<br /><applet load="1tow" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1tow" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1tow, resolution 2.00&Aring;" />
 '''Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand'''<br />
 ==Overview==
-Low micromolar human A-FABP inhibitors were found by utilizing a, fluorescence polarization assay, X-ray crystallography and modeling. The, carbazole- and indole-based inhibitors displayed approximately 10-fold, preferences over human H-FABP and E-FABP, and are highly selective against, I-FABP. This communication describes the SAR for drug-like synthetic, inhibitors of human A-FABP.
+Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.
 ==About this Structure==
-TOW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CRZ as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TOW OCA].
+TOW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CRZ:'>CRZ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOW OCA].
 ==Reference==
@@ Line 27: / Line 26: @@
 [[Category: transport]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:26:30 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:15:54 2008''