1rc2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,905 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,905 edits
No edit summary
Line 1: Line 1:
[[Image:1rc2.gif|left|200px]]
{{Seed}}
[[Image:1rc2.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rc2|  PDB=1rc2  |  SCENE=  }}  
{{STRUCTURE_1rc2|  PDB=1rc2  |  SCENE=  }}  


'''2.5 Angstrom Resolution X-ray Structure of Aquaporin Z'''
===2.5 Angstrom Resolution X-ray Structure of Aquaporin Z===




==Overview==
<!--
Aquaporins are a family of water and small molecule channels found in organisms ranging from bacteria to animals. One of these channels, the E. coli protein aquaporin Z (AqpZ), has been shown to selectively conduct only water at high rates. We have expressed, purified, crystallized, and solved the X-ray structure of AqpZ. The 2.5 A resolution structure of AqpZ suggests aquaporin selectivity results both from a steric mechanism due to pore size and from specific amino acid substitutions that regulate the preference for a hydrophobic or hydrophilic substrate. This structure provides direct evidence on the molecular mechanisms of specificity between water and glycerol in this family of channels from a single species. It is to our knowledge the first atomic resolution structure of a recombinant aquaporin and so provides a platform for combined genetic, mutational, functional, and structural determinations of the mechanisms of aquaporins and, more generally, the assembly of multimeric membrane proteins.
The line below this paragraph, {{ABSTRACT_PUBMED_14691544}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 14691544 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_14691544}}


==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Aquaporin]]
[[Category: Aquaporin]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:19:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:41:46 2008''

Revision as of 01:41, 28 July 2008

File:1rc2.png

Template:STRUCTURE 1rc2

2.5 Angstrom Resolution X-ray Structure of Aquaporin Z

Template:ABSTRACT PUBMED 14691544

About this Structure

1RC2 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z., Savage DF, Egea PF, Robles-Colmenares Y, O'Connell JD 3rd, Stroud RM, PLoS Biol. 2003 Dec;1(3):E72. Epub 2003 Dec 22. PMID:14691544

Page seeded by OCA on Mon Jul 28 04:41:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1rc2&oldid=681530"