1rcb: Difference between revisions

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[[Image:1rcb.~~gif~~|left|200px]]

[[Image:1rcb.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION~~'''~~

===CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION===

~~==Overview==~~

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The ~~crystal structure of human recombinant interleukin-4 (IL-4) has been solved by multiple isomorphous replacement~~, ~~and refined~~ to ~~an R factor of 0.218~~ at 2.~~25 A resolution~~. ~~The molecule~~ is ~~a left-handed four-helix bundle with a short stretch of beta sheet~~. ~~The structure bears close resemblance to other cytokines such as granulocyte~~-~~macrophage colony stimulating factor (GM~~-CSF). Although no sequence similarity of IL-4 to GM-CSF and other related cytokines has been previously postulated, structure-based alignment of IL-4 and GM-CSF revealed that the core of the molecules, including large parts of all four helices and extending over half of the molecule, has 30% sequence identity. This may have identified regions which are not only important to maintain structure, but could also play a role in receptor binding.

The line below this paragraph, {{ABSTRACT_PUBMED_1511746}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 1511746 is the PubMed ID number.

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==About this Structure==

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[[Category: Wlodaver, A.]]

[[Category: Cytokine]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 07~~:19:43 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:14:53 2008''

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-[[Image:1rcb.gif|left|200px]]
+{{Seed}}
+[[Image:1rcb.png|left|200px]]
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 {{STRUCTURE_1rcb|  PDB=1rcb  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION'''
+===CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION===
-==Overview==
+<!--
-The crystal structure of human recombinant interleukin-4 (IL-4) has been solved by multiple isomorphous replacement, and refined to an R factor of 0.218 at 2.25 A resolution. The molecule is a left-handed four-helix bundle with a short stretch of beta sheet. The structure bears close resemblance to other cytokines such as granulocyte-macrophage colony stimulating factor (GM-CSF). Although no sequence similarity of IL-4 to GM-CSF and other related cytokines has been previously postulated, structure-based alignment of IL-4 and GM-CSF revealed that the core of the molecules, including large parts of all four helices and extending over half of the molecule, has 30% sequence identity. This may have identified regions which are not only important to maintain structure, but could also play a role in receptor binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_1511746}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1511746 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_1511746}}
 ==About this Structure==
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 [[Category: Wlodaver, A.]]
 [[Category: Cytokine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:19:43 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:14:53 2008''